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Table 1 Main characteristics of the patients included

From: Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure

  cfDNA not reportable n = 58 cfDNA successful n = 295 p-value
Maternal age (years) 37 (35.7–40.1) 34 (29.6–37.1) < 0.001
Maternal weight (kg) 77 (60–90.3) 64 (56–70) < 0.001
Maternal height (cm) 165 (161.8–171) 165 (161–169) 0.53
BMI 29 (22.3–32.9) 23.7 (20.7–25.9) < 0.001
Ethnic group    0.14*
 Caucasian 41 (70.7) 237 (80.3)  
 Asian 1 (1.7) 13 (4.4)  
 Black or Caribbean 7 (12.1) 41 (13.9)  
 Other/unknown 9 (15.5) 4 (1.4)  
Cigarette smoker 4 (6.9) 1 (0.3)  
Nulliparous 22 (37.9) 18 (6.1) < 0.001
History of aneuploidy 3 (5.2) 9 (3.1)  
Medical condition
 Autoimmune disease 7 (12.1) 5 (1.7) < 0.001
 Repeated vein thrombosis 8 (13.8) 3 (1.0) < 0.001
 Other chronic condition 5 (8.6) 35 (11.9) 0.65
Heparin received 15 (25.9) 20 (6.8) < 0.001
Antiplatelet therapy 9 (15.5) 24 (8.1) 0.11
Any other treatment receiveda 14 (24.1) 75 (25.4) 0.96
Mode of conception    0.83
 Spontaneous 50 (86.2) 248 (84.1)  
 Assisted 8 (13.8) 47 (15.9)  
Reason for referral
 First-trimester screening 40 (70.0) 35 (11.9)  
 Second-semester screening 10 (17.2) 1 (0.3)  
 Maternal age 4 (6.9) 0  
 History of aneuploidy 4 (6.9) 1 (0.3)  
 Ultrasound abnormalities 0 19 (6.4)  
 First line screening 0 239 (81.0)  
  1. Data are given as mean (interquartile range) or n (%)
  2. 1 patient had a history of medical abortion for EDFR2 mutation
  3. * Caucasian versus other ethnic group
  4. aIncluding: nicardipine/hydroxychloroquine/digoxin/corticosteroids/chloroquine/levothyroxine