Fig. 5From: Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancerImmunohistochemical staining of PDXs. Examples of three PDXs derived from lung adenocarcinoma (cases 9 and 13) and squamous cell cancer (case 10) were stained with mouse anti-human CD4 and CD8 antibodies. CD8+ T cells were detected in all three samples, whereas CD4+ T cells were detected in case 13. Case 9 had CD8+ cells mainly in the stroma, case 10 had CD8+ cells mainly in the intraepithelial cancer structure, and case 13 had CD8+ cells in both stroma and intraepithelial cancer structure. Arrows indicate positive cellsBack to article page