Machine-learned models using hematological inflammation markers in the prediction of short-term acute coronary syndrome outcomes

Pieszko, Konrad; Hiczkiewicz, Jarosław; Budzianowski, Paweł; Rzeźniczak, Janusz; Budzianowski, Jan; Błaszczyński, Jerzy; Słowiński, Roman; Burchardt, Paweł

doi:10.1186/s12967-018-1702-5

Table 2 Basic characteristics of continuous numerical variables grouped by outcomes

From: Machine-learned models using hematological inflammation markers in the prediction of short-term acute coronary syndrome outcomes

	Feature	Unit	Significant lesion			No significant lesion			p-value	In-hospital death			No in—hospital death			p-value
	Feature	Unit	Support	Median	IQR	Support	Median	IQR	p-value	Support	Median	IQR	Support	Median	IQR	p-value
1	Age	Years	4825	65.8	14.3	1778	67	14.8	< 0.001	94	75.8	18.7	6509	66	14.3	< 0.001
2	Height	cm	4653	170	11	1743	170	11	0.059	70	169.5	10.3	6326	170	11	0.303
3	Weight	kg	4697	80	20	1748	80	20	0.707	75	78	21	6370	80	20	0.266
4	BMI	kg/m²	4643	27.7	6.5	1739	28.1	6.4	0.044	70	27	6.3	6312	27.8	6.5	0.173
5	Lymphocyte count	10 e⁻³/ul	4718	1.9	1	1719	1.8	0.9	< 0.001	84	1.7	1.5	6353	1.9	0.9	0.284
6	Monocyte count	10 e⁻³/ul	4718	0.6	0.3	1719	0.6	0.2	0.007	84	0.7	0.5	6353	0.6	0.3	< 0.001
7	Eosinophil count	10 e⁻³/ul	4718	0.1	0.1	1719	0.1	0.1	0.628	84	0	0.1	6353	0.1	0.1	< 0.001
8	Neutrophil count	10 e⁻³/ul	4703	5.2	2.9	1707	4.9	2.4	< 0.001	84	9.1	4.7	6326	5.1	2.8	< 0.001
9	Basophile count	10 e⁻³/ul	4718	0.1	0	1719	0.1	0	0.426	84	0.1	0	6353	0.1	0	0.732
10	Haemoglobin level	g/dl	4701	14.4	2.1	1715	14.3	2.1	0.103	83	12.8	3.1	6333	14.4	2.1	< 0.001
11	RDW	%	4634	12.2	1.3	1692	12.4	1.3	< 0.001	84	12.5	1.9	6242	12.2	1.4	0.004
12	Haematocrit	%	4707	42.4	5.9	1715	42.4	5.9	0.883	84	38	8.1	6338	42.5	5.9	< 0.001
13	MCV	fL	4718	90.9	6.3	1719	91.5	6.2	< 0.001	84	92.5	8.6	6353	91	6.2	0.129
14	Platelet count	10 e⁻³/ul	4718	223	79	1719	214	77	< 0.001	84	236	112	6353	221	78	0.392
15	MPV	fL	4682	8.5	2.1	1688	8.6	2.3	< 0.001	84	8.4	2.3	6286	8.5	2.2	0.238
16	NLR	Ratio	4703	2.7	2	1707	2.6	1.8	0.081	84	5.1	5	6326	2.6	1.9	< 0.001
17	PLR	Ratio	4718	115.3	65.6	1719	115.7	63.3	0.926	84	131.1	125.1	6353	115.2	64.4	0.097
18	Fibrinogen	mg/dl	4612	403	128	1715	398	124	0.357	83	439	173.5	6244	401	126	0.027
19	LDL	mg/dl	3561	109	66	1465	95	57	< 0.001	59	99	49.5	4967	104	64	0.236
20	HDL	mg/dl	3588	48	18	1480	51	21	< 0.001	59	45	16	5009	49	20	0.001
21	Total Cholesterol	mg/dl	3580	177	71	1474	164	65	< 0.001	59	163	61	4995	173	71	0.026
22	Triglycerides	mg/dl	3560	122	89	1469	117	78	0.004	59	109	78.5	4970	121	85	0.352
23	CRP	mg/dl	1067	0.7	3	443	0.4	1.4	< 0.001	36	5.5	9.4	1474	0.6	2.3	< 0.001
24	TSH	μU/ml	3975	1.3	1.2	1588	1.4	1.3	< 0.001	69	1.5	1.8	5494	1.3	1.3	0.127
25	Urea	mg/dl	3227	37	17	843	38	18	0.125	49	50	33	4021	37	17	< 0.001
26	Creatinine	mg/dl	4712	1	0.4	1727	1	0.4	0.011	84	1.3	0.6	6355	1	0.4	<0.001
27	GFR	ml/min	4468	76	29	1684	73	29	< 0.001	79	52	30.5	6073	75	29	< 0.001
28	Glycated Haemoglobin	%	349	6.4	1.9	69	6.4	1.6	0.731	7	7.9	1.8	411	6.3	1.8	0.009
29	Sodium	mmol/l	4766	141	4	1745	141	4	< 0.001	85	138	6	6426	141	4	< 0.001
30	Potassium	mmol/l	4765	4.4	0.6	1745	4.4	0.5	< 0.001	84	4.3	0.8	6426	4.4	0.6	0.8
31	Prothrombin time	s	4721	13.3	1.3	1748	13.4	1.5	0.065	87	15.2	3.2	6382	13.3	1.4	< 0.001
32	Thrombin time	s	4322	16	1.5	1680	16.1	1.4	< 0.001	73	16.3	2.5	5929	16	1.4	0.166
33	Heart rate at admission	1/min	4943	72	18	1826	72	18	0.166	97	79	30	6672	72	18	0.012
34	Systolic blood pressure	mmHg	4943	120	20	1826	120	20	0.044	97	100	40	6672	120	20	< 0.001
35	Diastolic blood pressure	mmHg	4943	80	17	1826	80	12	0.07	97	70	18	6672	80	12	< 0.001
36	Troponin I level	ng/l	2446	0	0.8	551	0	0.1	< 0.001	40	6.3	35.4	2957	0	0.6	< 0.001
37	Troponin T level	ng/l	2344	0	0.1	1210	0	0	< 0.001	42	0.5	1.7	3512	0	0.1	< 0.001
38	Alanine transaminase	U/l	2289	24	18	1077	23	16	0.012	47	29	47	3319	24	17	0.006
39	Aspartate transaminase	U/l	2321	24	16	1100	24	11	0.003	48	50	101.2	3373	24	14	< 0.001

The p-values apply to the univariate Mann–Whitney-U test
IQR inter-quartile range, BMI body mass index, RDW red cell distribution width, MCV mean cell volume, MPV mean platelet volume, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, LDL low density lipoprotein, HDL high-density lipoprotein, CRP C-reactive protein, TSH thyroid stimulating hormone, GFR glomerular filtration rate

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