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Table 3 Comparison of incidence and hazard ratio of depression stratified by sex, age and comorbidity between with and without Scrub typhus patients

From: Scrub typhus and depression: a nationwide cohort analysis

Variable

Without scrub typhus

With scrub typhus

Event

Person-years

Ratea

Crude HR

Event

Person-years

Ratea

Crude HR (95% CI)

Adjusted HRb (95% CI)

Sex

 Female

51

37,459

1.36

Reference

21

9232

2.27

1.67 (1.43, 1.95)*

1.68 (1.45, 1.96)*

 Male

66

70,973

0.93

Reference

24

17,672

1.36

1.46 (1.29, 1.65)*

1.46 (1.29, 1.64)*

P for interaction

        

0.16

Stratify age

 ≤ 49

52

65,025

0.80

Reference

25

16,123

1.55

1.94 (1.71, 2.19)*

1.95 (1.72, 2.20)*

 50–64

35

28,372

1.23

Reference

15

7028

2.13

1.73 (1.46, 2.06)*

1.73 (1.46, 2.05)*

 65 +

30

15,036

2.00

Reference

5

3753

1.33

0.67 (0.50, 1.02)

0.69 (0.52, 1.01)

P for interaction

        

< 0.001

Comorbidityc

 No

61

87,465

0.70

Reference

31

21,555

1.44

2.06 (1.85, 2.29)*

2.06 (1.85, 2.29)*

 Yes

56

20,968

2.67

Reference

14

5350

2.62

0.98 (0.80, 1.20)

0.98 (0.80, 1.20)

P for interaction

        

< 0.001

  1. aIncidence rate, per 1000 person-years; Crude HR, crude hazard ratio
  2. bMultivariable analysis including age, and comorbidities of diabetes, hypertension, hyperlipidemia, CAD and stroke
  3. cPatients with any one of the comorbidities diabetes, hypertension, hyperlipidemia, CAD and stroke were classified as the comorbidity group
  4. * P < 0.05