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Table 3 Comparison of incidence and hazard ratio of depression stratified by sex, age and comorbidity between with and without Scrub typhus patients

From: Scrub typhus and depression: a nationwide cohort analysis

Variable Without scrub typhus With scrub typhus
Event Person-years Ratea Crude HR Event Person-years Ratea Crude HR (95% CI) Adjusted HRb (95% CI)
Sex
 Female 51 37,459 1.36 Reference 21 9232 2.27 1.67 (1.43, 1.95)* 1.68 (1.45, 1.96)*
 Male 66 70,973 0.93 Reference 24 17,672 1.36 1.46 (1.29, 1.65)* 1.46 (1.29, 1.64)*
P for interaction          0.16
Stratify age
 ≤ 49 52 65,025 0.80 Reference 25 16,123 1.55 1.94 (1.71, 2.19)* 1.95 (1.72, 2.20)*
 50–64 35 28,372 1.23 Reference 15 7028 2.13 1.73 (1.46, 2.06)* 1.73 (1.46, 2.05)*
 65 + 30 15,036 2.00 Reference 5 3753 1.33 0.67 (0.50, 1.02) 0.69 (0.52, 1.01)
P for interaction          < 0.001
Comorbidityc
 No 61 87,465 0.70 Reference 31 21,555 1.44 2.06 (1.85, 2.29)* 2.06 (1.85, 2.29)*
 Yes 56 20,968 2.67 Reference 14 5350 2.62 0.98 (0.80, 1.20) 0.98 (0.80, 1.20)
P for interaction          < 0.001
  1. aIncidence rate, per 1000 person-years; Crude HR, crude hazard ratio
  2. bMultivariable analysis including age, and comorbidities of diabetes, hypertension, hyperlipidemia, CAD and stroke
  3. cPatients with any one of the comorbidities diabetes, hypertension, hyperlipidemia, CAD and stroke were classified as the comorbidity group
  4. * P < 0.05