Fig. 2
µCT assessment of bone healing. a Representative µCT reconstructions of 4 week 5 mm critical sized calvarial defect healing from above (above) and in cross-section (below) for both ACS (top) and ACS/Talymed (bottom) treated individuals. Healing in the defect area has been highlighted and BMP2 dose increases from left to right. Note the similar healing between medium and high doses of BMP2 and the dramatic ectopic bone highlighted in the clinical dose of BMP2. b Assessment of bone volume/tissue volume confirms greater healing with medium and high doses of BMP2 and less healing with the clinical dose. c A secondary analysis of the ectopic bone not included within the surgical plane confirmed a dose dependent increase in aberrant bone. n = 9 or 10 per group **p ≤ 0.01, ***p ≤ 0.001