Table 1 Derived glycan traits defined from directly measured glycan peaks
Derived plasma glycan trait | Description | Formula | Example of a glycan structure |
|---|---|---|---|
LB | Proportion of mono- and biantennary structures in the total plasma N-glycome | GP1 + GP2/2 + GP3 + GP4 + GP5 + GP6 + GP8 + GP9 + GP10 + GP11 + GP12 + GP13 + GP14 + GP15 + GP16 + GP17 + GP18 + GP20 + GP21 + GP22 + GP23 |
|
HB | Proportion of tri- and tetraantennary structures in the total plasma N-glycome | GP24 + GP25 + GP26 + GP27 + GP28 + GP29 + GP30 + GP31 + GP32 + GP33 + GP34 + GP35 + GP36 + GP37 + GP38 + GP39 |
|
G0 | Proportion of agalactosylated structures in the total plasma N-glycome | GP1 + GP2/2 |
|
G1 | Proportion of monogalactosylated structures in the total plasma N-glycome | GP3 + GP4 + GP5 + GP6 + GP12 + GP13 |
|
G2 | Proportion of digalactosylated structures in the total plasma N-glycome | GP8 + GP9 + GP10 + GP11 + GP14 + GP15 + GP16 + GP17 + GP18 + GP20 + GP21 + GP22 + GP23 |
|
G3 | Proportion of trigalactosylated structures in the total plasma N-glycome | GP24 + GP25 + GP26 + GP27 + GP28 + GP29 + GP30 + GP31 + GP32 + GP35 |
|
G4 | Proportion of tetragalactosylated structures in the total plasma N-glycome | GP33 + GP34 + GP36 + GP37 + GP38 + GP39 |
|
S0 | Proportion of asialylated structures in the total plasma N-glycome | GP1 + GP2/2 + GP3 + GP4 + GP5 + GP6 + GP8 + GP9 + GP10 + GP11 |
|
S1 | Proportion of monosialylated structures in the total plasma N-glycome | GP12 + GP13 + GP14 + GP15 + GP16 + GP17 |
|
S2 | Proportion of disialylated structures in the total plasma N-glycome | GP18 + GP20 + GP21 + GP22 + GP23 + GP24 + GP25 + GP26 |
|
S3 | Proportion of trisialylated structures in the total plasma N-glycome | GP27 + GP28 + GP29 + GP30 + GP31 + GP32 + GP33 + GP34 + GP35 |
|
S4 | Proportion of tetrasialylated structures in the total plasma N-glycome | GP36 + GP37 + GP38 + GP39 |
|
Bisecting | Proportion of structures containing bisecting GlcNAc in the total plasma N-glycome | GP2/2 + GP3 + GP6 + GP9 + GP11 + GP12 + GP15 + GP17 + GP21 + GP23 |
|
OligoMan | Proportion of oligomannosidic structures in the total plasma N-glycome | GP2/2 + GP7 + GP19 |
|
CoreF | Proportion of structures containing core fucose in the total plasma N-glycome | GP1 + GP2/2 + GP4 + GP5 + GP6 + GP10 + GP11 + GP13 + GP16 + GP17 + GP22 + GP23 + GP29 + GP31 |
|
AntF | Proportion of structures containing antennary fucose in the total plasma N-glycome | GP32 + GP35 + GP39 |
|
Derived IgG glycan trait | Description | Formula | Example of a glycan structure |
|---|---|---|---|
G0 | Proportion of agalactosylated structures in the total IgG N-glycome | IGP1 + IGP2 + IGP3 + IGP4 + IGP5 + IGP6 |
|
G1 | Proportion of monogalactosylated structures in the total IgG N-glycome | IGP7 + IGP8 + IGP9 + IGP10 + IGP11 + IGP16 |
|
G2 | Proportion of digalactosylated structures in the total IgG N-glycome | IGP12 + IGP13 + IGP14 + IGP15 + IGP17 + IGP18 + IGP19 + IGP21 + IGP22 + IGP23 + IGP24 |
|
S0 | Proportion of asialylated structures in the total IgG N-glycome | IGP1 + IGP2 + IGP3 + IGP4 + IGP5 + IGP6 + IGP7 + IGP8 + IGP9 + IGP10 + IGP11 + IGP12 + IGP13 + IGP14 + IGP15 |
|
S1 | Proportion of monosialylated structures in the total IgG N-glycome | IGP16 + IGP17 + IGP18 + IGP19 |
|
S2 | Proportion of disialylated structures in the total IgG N-glycome | IGP21 + IGP22 + IGP23 + IGP24 |
|
Bisecting | Proportion of structures containing bisecting GlcNAc in the total IgG N-glycome | IGP3 + IGP6 + IGP10 + IGP11 + IGP13 + IGP15 + IGP19 + IGP22 + IGP24 |
|
OligoMan | Proportion of oligomannosidic structures in the total IgG N-glycome | IGP5 |
|
CoreF | Proportion of structures containing core fucose in the total IgG N-glycome | IGP1 + IGP4 + IGP6 + IGP8 + IGP9 + IGP10 + IGP11 + IGP14 + IGP15 + IGP16 + IGP18 + IGP19 + IGP23 + IGP24 |
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