From: Serum uromodulin and progression of kidney disease in patients with chronic kidney disease
Characteristics | Total (N = 2652) | Serum uromodulin tertiles (ng/mL) | ||
---|---|---|---|---|
≤ 52.7 (N = 885) | > 52.7–100.8 (N = 881) | > 100.8 (N = 886) | ||
Age (years) | 48.7 ± 13.8 | 50.2 ± 13.6 | 50.0 ± 13.2 | 45.9 ± 14.1 |
Male (n%) | 1548 (58.4%) | 513 (58.0%) | 534 (60.6%) | 501 (56.6%) |
Body mass index (kg/m2) | 24.4 ± 3.6 | 24.2 ± 3.7 | 24.7 ± 3.7 | 24.4 ± 3.5 |
Systolic blood pressure (mmHg) | 130.1 ± 19.3 | 135.7 ± 20.5 | 130.4 ± 18.4 | 124.7 ± 17.7 |
Diastolic blood pressure (mmHg) | 81.3 ± 11.7 | 83.6 ± 12.4 | 81.6 ± 11.7 | 78.8 ± 10.4 |
Smoking status (n%) | 907 (38.1%) | 325 (42.4%) | 300 (38.2%) | 282 (34.0%) |
Diabetes (n%) | 516 (19.6%) | 178 (20.3%) | 202 (23.1%) | 136 (15.4%) |
Using anti-hypertensive medications in the past 2Â weeks (n%) | 1488 (73.2%) | 540 (82.3%) | 524 (76.7%) | 424 (61.1%) |
Cardiovascular disease (n%) | 293 (12.2%) | 121 (15.6%) | 114 (14.2%) | 58 (7.0%) |
Triglyceride (mmol/L) | 1.8 (1.3, 2.6) | 1.8 (1.3, 2.6) | 1.8 (1.3, 2.7) | 1.7 (1.2, 2.4) |
Total cholesterol (mmol/L) | 4.8 (4.0, 5.8) | 4.5 (3.7, 5.4) | 4.9 (4.1, 5.9) | 5.0 (4.1, 6.2) |
High-density lipoprotein cholesterol (mmol/L) | 1.1 (0.9, 1.3) | 1.0 (0.9, 1.2) | 1.1 (0.9, 1.3) | 1.2 (1.0, 1.4) |
Low-density lipoprotein cholesterol (mmol/L) | 2.6 (2.1, 3.3) | 2.4 (2.0, 3.0) | 2.6 (2.1, 3.3) | 2.8 (2.2, 3.5) |
Fasting blood glucose (mmol/L) | 4.9 (4.4, 5.6) | 4.9 (4.4, 5.6) | 5.0 (4.4, 5.7) | 4.9 (4.4, 5.5) |
Prealbumin (g/L) | 326.5 ± 83.1 | 348.7 ± 87.6 | 327.6 ± 79.3 | 303.2 ± 75.6 |
High sensitive–reactive protein (mg/L) | 1.3 (0.5, 3.0) | 1.5 (0.6, 3.6) | 1.4 (0.6, 3.1) | 1.0 (0.4, 2.5) |
Urinary albumin/creatinine ratio (mg/g) | 473.7 (134.1, 1046.6) | 661.7 (233.9, 1352.8) | 439.9 (113.2, 969.9) | 374.3 (100.0, 836.6) |
Creatinine (μmol/L) | 173.8 ± 121.8 | 247.4 ± 138.6 | 165.7 ± 114.5 | 108.4 ± 49.1 |
Estimated glomerular filtration rate (mL/min/1.73 m2) | 49.6 ± 29.4 | 28.5 ± 15.0 | 46.3 ± 23.0 | 74.0 ± 28.0 |
Estimated glomerular filtration rate group (mL/min/1.73Â m2) | ||||
 ≥ 90 | 337 (12.7%) | 5 (0.6%) | 58 (6.6%) | 274 (30.9%) |
 60–89 | 451 (17.0%) | 31 (3.5%) | 111 (12.6%) | 309 (34.9%) |
 45–59 | 419 (15.8%) | 73 (8.3%) | 211 (24.0%) | 135 (15.2%) |
 30–44 | 634 (23.9%) | 211 (23.8%) | 297 (33.7%) | 126 (14.2%) |
 15–29 | 811 (30.6%) | 565 (63.8%) | 204 (23.2%) | 42 (4.7%) |