Fig. 4From: Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCsCT analysis and gross appearance of the repair of the goat skull defect. a1–a3 3D reconstruction of the CT of the cranial defect location repaired by Fetal-TEBG in young goats, 1.5 months, 3 months, 6 months. a4 General view of the cranial defect location repaired by Fetal-TEBG in young goats. b1–b3 3D reconstruction of the CT of the cranial defect location repaired by Control DBM scaffold in young goats, 1.5 months, 3 months, 6 months. b4 General view of the cranial defect location repaired Control DBM scaffold in young goats. c1–c3 3D reconstruction of the CT of the cranial defect location repaired by Fetal-TEBG in aged goats, 1.5 months, 3 months, 6 months. c4 General view of the cranial defect location repaired Fetal-TEBG in aged goats. d1–d3 3D reconstruction of the CT of the cranial defect location repaired by Control DBM scaffold in aged goats, 1.5 months, 3 months, 6 months. d4 General view of the cranial defect location repaired Control DBM scaffold in aged goats. e1, e2 1.5 months: the bone volume (BV) and bone volume/tissue volume ratio (BV/TV) in the skull defect area of Fetal-TEBG/Young group was more than that of Fetal-TEBG/Aged group (p < 0.05); In the Control DBM groups, the bone volume (BV) and bone volume/tissue volume ratio (BV/TV) of the young goats was also significantly higher than that of the aged goats (p < 0.05). f1, f2 3 months: the bone volume (BV) and bone volume/tissue volume ratio (BV/TV) in the skull defect area of Fetal-TEBG/Young group was more than that of Fetal-TEBG/Aged group (p < 0.05); In the Control DBM groups, the bone volume (BV) of the young goats was also significantly higher than that of the aged goats (p < 0.05). g1, g2 6 months: the bone volume (BV) and bone volume/tissue volume ratio (BV/TV) in the skull defect area of Fetal-TEBG/Young group was more than that of Fetal-TEBG/Aged group (p < 0.05); In the Control DBM groups, the bone volume (BV) and bone volume/tissue volume ratio (BV/TV) of the young goats was also significantly higher than that of the aged goats (p < 0.05)Back to article page