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Table 2 Univariate and multivariate Cox regression analyses of the risk genes for non-small cell lung cancer brain metastasis

From: GAP43, a novel metastasis promoter in non-small cell lung cancer

Factorsa

HR

95% CI

P value

Univariate analysis

 BMI1

0.58

0.29–1.16

0.124

 POU5F1

0.75

0.38–1.47

0.397

 KLF4

1.11

0.57–2.18

0.757

 SMO

0.86

0.43–1.68

0.650

 JAG1

0.85

0.43–1.67

0.634

 SPARC

1.44

0.73–2.84

0.292

 ST6GALNAC5

1.90

0.95–3.81

0.071

 SNAI1

1.89

0.96–3.74

0.066

 TNF

1.23

0.63–2.41

0.545

 CXCR5

0.77

0.39–1.51

0.448

 GFAP

1.00

0.51–1.96

0.995

 DYNC1LI2

1.13

0.58–2.21

0.729

 MMP3

1.21

0.62–2.37

0.579

 CDH2

1.87

0.94–3.71

0.073

 EGFR

0.65

0.33–1.28

0.212

 VCAN

1.50

0.76–2.97

0.247

 HGF

0.76

0.39–1.50

0.427

 CTNNB1

0.76

0.39–1.50

0.428

 CXCR4

1.46

0.74–2.88

0.275

 KIF3A

1.47

0.74–2.89

0.269

 GPM6A

0.70

0.36–1.38

0.307

 HBEGF

0.95

0.48–1.86

0.869

 CXCL13

0.99

0.51–1.95

0.985

 TGFB2

0.92

0.47–1.80

0.803

 PLP1

0.81

0.39–1.69

0.568

 TWIST1

1.45

0.74–2.86

0.280

 PTGS2

0.87

0.44–1.71

0.679

 BPTF

0.77

0.39–1.52

0.443

 FABP7

1.92

0.96–3.83

0.066

 GAP43

2.12

1.09–4.13

0.027

 PMP2

2.12

1.05–4.30

0.036

 UGT8

1.23

0.63–2.41

0.549

 GPM6B

1.00

0.51–1.96

0.990

 FAM107A

0.62

0.31–1.23

0.169

 IL8

1.27

0.65–2.49

0.492

 MMP9

1.16

0.59–2.27

0.668

Multivariate analysisb

 GAP43

3.29

1.55–7.00

0.002

 SNAI1

1.98

1.00–3.95

0.051

 Grade

2.08

1.00–4.34

0.051

  1. HR hazard ratio, CI confidence interval
  2. Italic values were statistically significant (P < 0.05)
  3. aFactors were analyzed as categorical variables, and low-expression groups or well-differentiated groups were referred
  4. bGenes whose P values were < 0.1 in univariate analyses and clinicopathologic factors were involved in the multivariate Cox regression analysis, and the Forward LR (based on partial maximum likelihood estimation) was used to identify independent risk factors