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Table 4 Anthropometric, body composition and REE analysis for FTO rs9939609 A carriers vs TT genotype in MeD and CTR groups

From: Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial

 

TT genotype

A carriers

P main effect of FTO rs9939609

P main effect of diet

P main effect gene-diet interaction

MeD

CTR

MeD

CTR

(n = 40)

(n = 17)

(n = 99)

(n = 32)

Weight (kg)

    

0.85

0.43

0.87

 Baseline

79.63 (21.56)

73.33 (17.26)

83.29 (22.73)

78.73 (15.87)

   

 Change

− 3.41 (6.47)

− 1.27 (3.89)

− 2.25 (11.79)

− 0.62 (1.26)

   

BMI

    

0.92

0.33

0.81

 Baseline

29.03 (7.39)

25.74 (3.64)

30.4 (7.35)

28.50 (6.03)

   

 Change

− 1.28 (2.34)

− 0.30 (0.82)

− 0.85 (4.27)

− 0.18 (0.80)

   

Neck circumference (cm)

    

0.50

0.78

0.37

 Baseline

40.54 (3.39)

36.75 (3.28)

41.03 (4.19)

36.88 (3.76)

   

 Change

− 0.60 (0.42)

− 0.40 (0.96)

− 1.09 (2.13)

− 0.07 (1.12)

   

Waist circumference (cm)

    

0.80

0.87

0.86

 Baseline

88.17 (19.18)

86.81 (11.66)

94.14 (17.25)

87.7 (12.72)

   

 Change

− 1.10 (3.03)

− 0.78 (1.82)

− 1.91 (7.55)

− 1.10 (2.34)

   

Abdomen circumference (cm)

    

0.87

0.97

0.28

 Baseline

104.92 (18)

93.74 (9.66)

107.49 (15.9)

99.48 (14.6)

   

 Change

− 0.80 (1.48)

− 1.04 (3.46)

− 3.73 (6.51)

− 1.13 (2.89)

   

Hip circumference (cm)

    

0.93

0.70

0.76

 Baseline

103.8 (11.16)

102.72 (7.68)

107.68 (13.01)

107.67 (12.13)

   

 Change

− 1.90 (4.04)

− 1.38 (3.55)

− 2.51 (3.93)

− 1.44 (3.29)

   

WHR

    

0.80

0.89

0.89

 Baseline

0.84 (0.12)

0.84 (0.08)

0.87 (0.12)

0.82 (0.08)

   

 Change

0.00 (0.02)

0.00 (0.03)

0.00 (0.07)

0.00 (0.03)

   

R

    

0.10

0.98

0.87

 Baseline

533.35 (88.18)

545.31 (80.2)

484.66 (107.09)

507.77 (78.38)

   

 Change

− 3.00 (22.26)

0.24 (33.1)

20.11 (59.77)

25.91 (42.27)

   

Xc

    

0.38

0.32

0.38

 Baseline

55.8 (11.45)

58.81 (8.83)

54.98 (15.84)

54.84 (10.33)

   

 Change

0.00 (4.76)

− 4.53 (6.69)

− 2.2 (10.33)

− 2.13 (8.13)

   

PA

    

0.73

0.45

0.58

 Baseline

6.23 (1.06)

6.24 (1.22)

6.62 (1.54)

6.22 (1.07)

   

 Change

0.10 (0.34)

− 0.40 (0.79)

− 0.47 (1.57)

− 0.53 (0.94)

   

BCM (kg)

    

0.17

0.91

0.94

 Baseline

27.29 (6.39)

28.95 (8.13)

31.99 (9.68)

29.66 (6.28)

   

 Change

− 0.33 (0.98)

− 0.54 (3.51)

− 2.62 (7.63)

− 2.75 (4.26)

   

Na/K

    

0.64

0.66

0.53

 Baseline

0.97 (0.12)

0.98 (0.13)

0.91 (0.18)

0.96 (0.13)

   

 Change

0.03 (0.1)

0.06 (0.1)

0.06 (0.17)

− 0.12 (0.63)

   

TBW (L)

    

0.02*

0.48

0.47

 Baseline

38.36 (8.55)

38.54 (8.94)

41.76 (10.99)

39.81 (6.57)

   

 Change

− 0.83 (1.63)

0.70 (3.04)

− 1.88 (4.35)

− 1.75 (3.28)

   

ECW (L)

    

0.81

0.43

0.56

 Baseline

17.23 (4.06)

17.22 (3.9)

18.01 (5.27)

17.89 (3.04)

   

 Change

− 0.25 (1.5)

2.00 (3.26)

2.16 (6.74)

2.42 (4.07)

   

ICW (L)

    

0.65

0.92

0.81

 Baseline

21.12 (5.16)

17.22 (3.9)

23.75 (6.97)

20.59 (4.05)

   

 Change

− 0.25 (0.74)

− 0.54 (1.8)

− 1.89 (4.85)

− 0.95 (1.79)

   

BCMI

    

0.70

0.91

0.52

 Baseline

12.77 (7.02)

10.11 (1.96)

13.9 (8.08)

10.56 (1.94)

   

 Change

− 0.10 (0.34)

− 0.34 (1)

− 2.40 (6.81)

− 0.85 (1.23)

   

Android Bfat (%)

    

0.60

0.09

0.93

 Baseline

44.92 (12.45)

37.34 (8.78)

44.88 (12.77)

39.79 (12.61)

   

 Change

− 4.52 (6.01)

− 1.00 (2.16)

− 2.96 (4.64)

0.15 (1.7)

   

Gynoid Bfat (%)

    

0.70

0.04*

0.32

 Baseline

43.51 (10.63)

36 (7.85)

41.8 ( 77(11.76)

39.07 (9.37)

   

 Change

− 2.94 (5.14)

0.03 (1.26)

− 1.67 (3.51)

− 0.42 (1.74)

   

TBFat (%)

    

0.79

0.08

0.94

 Baseline

37.92 (9.45)

33.16 (6.05)

38.08 (10.34)

36.14 (9.52)

   

 Change

− 2.74 (3.45)

− 0.19 (1.14)

− 2.01 (3.65)

0.31 (0.9)

   

Android Bfat (kg)

    

0.89

0.27

0.91

 Baseline

3.02 (1.96)

2.32 (1.08)

3.3 (2.17)

2.78 (1.39)

   

 Change

− 0.47 (0.53)

− 0.04 (0.27)

− 0.45 (1.18)

− 0.12 (0.63)

   

Gynoid Bfat (kg)

    

0.49

0.84

0.40

 Baseline

5.57 (2.19)

4.37 (1.45)

5.49 (2.58)

5.78 (1.79)

   

 Change

− 0.62 (0.85)

− 0.46 (1.25)

− 0.36 (2.82)

− 0.94 (2.25)

   

TBFat (Kg)

    

0.06

0.00*

0.04*

 Baseline

31.34 (14.5)

21.32 (8.66)

32.85 (15.56)

23.24 (12.11)

   

 Change

− 3.59 (4.78)

1.93 (5.54)

− 3.97 (6.97)

6.11 (9.60)

   

Android BLean (kg)

    

0.97

0.32

0.12

 Baseline

3.32 (1.01)

3.31 (0.86)

3.2 (0.91)

3.31 (0.62)

   

 Change

− 0.22 (0.87)

− 0.08 (0.15)

0.11 (0.6)

− 0.08 (0.27)

   

Gynoid BLean (kg)

    

0.49

0.92

0.91

 Baseline

6.77(1.86)

7.24(2.16)

6.79(1.9)

7.08(1.26)

   

 Change

− 0.20(1.54)

− 0.18(0.31)

− 0.56(5.66)

0.01(0.33)

   

TBLean (kg)

    

0.92

0.63

0.87

 Baseline

47.67(11.77)

46.47(11.84)

47.86(11.37)

47.28(8.87)

   

 Change

− 1.23(6.82)

− 0.53(1.05)

− 0.56(5.66)

− 0.61(2.08)

   

REE

    

0.77

0.27

0.49

 Baseline

1639.92 (409.68)

1664.96 (217.89)

1628.13 (347.37)

1583.46 (313.51)

   

 Change

− 48.13 (327.01)

− 31.44 (140.89)

− 44.01 (220.32)

− 7.49 (34.75)

   
  1. Relationship between FTO rs9939609 A carriers and TT genotype in body composition and metabolism, according to MeD and CTR groups. Statistical significance (*) were given to results with p < 0.05 through GLM analysis. BMI body mass index, WHR waist hip ratio, R resistance, Xc reactance, PA phase angle, HYDR hydration, NA/K sodium–potassium exchange, TBW total body water, ECW extracellular water, ICW intracellular water, BFat body fat, TBFat total body fat, BLean body lean, TBLean total body lean, REE resting energy expenditure
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Journal of Translational Medicine

ISSN: 1479-5876

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