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Table 3 Multivariable Cox regression

From: Fragment size and level of cell-free DNA provide prognostic information in patients with advanced pancreatic cancer

Parameter Progression-free survival Overall survival
Hazard ratio (95% CI) p-value Hazard ratio (95% CI) p-value
cfDNA level B1 (> median vs ≤ median) 3.049 (1.398–6.649) 0.005 2.236 (1.089–4.590) 0.028
CA 19-9 (< 37U/mL vs ≥ 37U/mL)   n.s. 0.345 (0.148–0.804) 0.014
ECOG performance status   0.043   0.011
 0 Reference   Reference  
 1 1.122 (0.486–2.589)   1.149 (0.540–2.446)  
 2 3.108 (1.066–9.056)   4.066 (1.443–11.461)  
First line treatment   0.003   < 0.001
 FOLFIRINOX Reference   Reference  
 Gemcitabine 7.765 (2.313–26.068)   12.064 (3.385–42.996)  
 Nab-Pac + gemcitabine 2.021 (1.002–4.076)   2.901 (1.411–5.965)  
  1. n.s. not significant