Table 3 The tumor volume with anti-PD-1 and/or anti-CD25 associated with anti-TGF-β treatment in different periods

Anti-PD-1

5

0.49 ± 0.45

3.02 ± 3.38

10.81 ± 9.82

39.71 ± 27.06

163.50 ± 117.02

Anti-TGF-β⁺ anti-CD25

5

1.56 ± 1.68

7.61 ± 7.08

34.94 ± 30.67

55.28 ± 41.42

129.87 ± 29.75

Anti-PD-1⁺ anti-TGF-β⁺ anti-CD25

5

1.93 ± 1.74

1.46 ± 2.09

1.84 ± 4.04

6.32 ± 14.13

13.31 ± 29.76

Multiple comparision p value

1 vs. 2

0.205

0.227

0.132

0.502

0.906

1 vs. 3

0.139

0.411

0.114

0.050

0.043

2 vs. 3

0.742

0.099

0.044

0.037

0.046