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Table 1 Univariate and multivariate analysis of prognostic factors associated with overall survival

From: CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Characteristics

Patients

Overall survival

Univariate analysis p value

Multivariate analysis p value

Multivariate HR

95% confidence interval (CI)

Total

90

    

Gender

 Male/female

56/34

0.782

NA

  

Age (years)

 < 70/≥ 70

64/26

0.261

NA

  

Primary site

 Head/body or tail

52/38

0.397

NA

  

Differentiation

 I/II/III

1/28/61

0.303

NA

  

T classification

 ≤ 4 cm/> 4 cm

66/24

0.039

0.047

1.737

1.006–2.998

N classification

 N0/N1–2

53/37

0.045

0.037

1.741

1.035–2.927

Fibrinogen

 ≤ 400/> 400 mg/dL

75/15

0.319

NA

  

CA19-9

 < 37/≥ 37 U/L

22/68

0.207

NA

  

CEA

 < 5/≥ 5 ng/mL

68/22

0.619

NA

  

TBIL

 ≤ 20.4/> 20.4 μmol/L

56/34

0.237

NA

  

Albumin

 < 35/≥ 35 g/L

16/74

0.805

NA

  

ALT

 ≤ 35/> 35 U/L

50/40

0.441

NA

  

AST

 ≤ 40/> 40 U/L

54/36

0.672

NA

  

GGT

 ≤ 60/> 60 U/L

45/45

0.766

NA

  

ALP

 ≤ 125/> 125 U/L

54/36

0.588

NA

  

LDH

 ≤ 245/> 245 U/L

76/14

0.336

NA

  

Glucose

 ≤ 5.6/> 5.6 mmol/L

38/52

0.090

NA

  

TGF-β

 Low/high

50/40

< 0.001

0.001

2.453

1.410–4.266

IIR

 Low/high

30/60

0.006

0.032

2.004

1.063–3.779

  1. Italic values indicate significance of p value (p<0.05)