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Table 1 Univariate and multivariate analysis of prognostic factors associated with overall survival

From: CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Characteristics Patients Overall survival
Univariate analysis p value Multivariate analysis p value Multivariate HR 95% confidence interval (CI)
Total 90     
Gender
 Male/female 56/34 0.782 NA   
Age (years)
 < 70/≥ 70 64/26 0.261 NA   
Primary site
 Head/body or tail 52/38 0.397 NA   
Differentiation
 I/II/III 1/28/61 0.303 NA   
T classification
 ≤ 4 cm/> 4 cm 66/24 0.039 0.047 1.737 1.006–2.998
N classification
 N0/N1–2 53/37 0.045 0.037 1.741 1.035–2.927
Fibrinogen
 ≤ 400/> 400 mg/dL 75/15 0.319 NA   
CA19-9
 < 37/≥ 37 U/L 22/68 0.207 NA   
CEA
 < 5/≥ 5 ng/mL 68/22 0.619 NA   
TBIL
 ≤ 20.4/> 20.4 μmol/L 56/34 0.237 NA   
Albumin
 < 35/≥ 35 g/L 16/74 0.805 NA   
ALT
 ≤ 35/> 35 U/L 50/40 0.441 NA   
AST
 ≤ 40/> 40 U/L 54/36 0.672 NA   
GGT
 ≤ 60/> 60 U/L 45/45 0.766 NA   
ALP
 ≤ 125/> 125 U/L 54/36 0.588 NA   
LDH
 ≤ 245/> 245 U/L 76/14 0.336 NA   
Glucose
 ≤ 5.6/> 5.6 mmol/L 38/52 0.090 NA   
TGF-β
 Low/high 50/40 < 0.001 0.001 2.453 1.410–4.266
IIR
 Low/high 30/60 0.006 0.032 2.004 1.063–3.779
  1. Italic values indicate significance of p value (p<0.05)