Fig. 1

Study design and stages of anthracycline cardiotoxicity. A schematic of the timing of the ¹⁸FDG positron emission tomography (¹⁸FDG-PET) scans and echocardiograms taken into analysis is depicted in the upper panel, while the corresponding stages of anthracycline-related cardiotoxicity are presented in the lower part. DOX: doxorubicin-containing chemotherapy; ECHO^PRE: echocardiography at baseline (available only in a subgroup of patients); ECHO^POST: echocardiography after completion of DOX chemotherapy; PET^STAGING: ¹⁸FDG-PET before treatment; PET^INTERIM: ¹⁸FDG-PET after 2 cycles of doxorubicin; PET^EOT: ¹⁸FDG-PET at the end of treatment; LV: left ventricular