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Table 1 Patient and tumor characteristics in the neoadjuvant cohort

From: Podocalyxin-like protein as a predictive biomarker for benefit of neoadjuvant chemotherapy in resectable gastric and esophageal adenocarcinoma

 

Patients n (%)

N

148

Age (years)

 Mean

63.2

 Median

65.2

 Range

21.1–81.0

Sex

 Female

58 (39.2)

 Male

90 (60.8)

Location

 Esophagus

62 (41.9)

 Stomach

86 (58.1)

cT stage

 T1

1 (0.7)

 T2

54 (36.5)

 T3

87 (58.8)

 T4

6 (4.1)

cN stage

 N0

80 (54.1)

 N1

50 (33.8)

 N2

14 (9.5)

 N3

4 (2.7)

cM stage

 M0

136 (91.9)

 M1

12 (8.1)

  Lymph node metastasis in M1-position

6

  Liver metastasis

3

  Adrenal gland metastasis

1

  Ovarian metastasis

1

  Ascites

1

Neoadjuvant treatment

 Chemotherapy NOS

148

  Fluoropyrimidine + platinum ≥ 8 weeks, no irinotecan

121 (81.8)

Resection

 Yes

118 (79.7)

 No

30 (20.3)

  Peroperative findings of advanced disease

20

  Liver metastasis found after one cycle of chemotherapy

1

  Progressive disease

1

  Deteriorated performance status

3

  Death

2

  Patient’s wish

3

Adjuvant treatment

 Chemotherapy NOS

78 (66.7)

  Fluoropyrimidine + platinum ≥ 8 weeks, no irinotecan

46

 Chemoradiotherapy

10 (8.5)

 None

29 (24.8)

 Missing data

1

 No surgery

30

Histopathologic response

 0% residual cancer cells

13 (11.1)

 1–10%

13 (11.1)

 11–50%

46 (39.3)

  > 50%

45 (38.5)

 Missing data

1

 No surgery

30

ypT stage

 T0

13 (11.1)

 T1

14 (12.0)

 T2

22 (18.8)

 T3

42 (35.9)

 T4

26 (22.2)

 Missing data

1

 No surgery

30

ypN stage

 N0

52 (44.1)

 N1

28 (23.7)

 N2

18 (15.3)

 N3

20 (16.9)

 No surgery

30

ypM stage

 M0

113 (95.8)

 M1

5 (4.2)

  Lymph node metastasis in M1-position

1

  Liver metastasis

1

  Ovarian metastasis

1

  Peritoneal deposit

2

 No surgery

30

Residual tumor status

 R0

97 (82.2)

 R1

19 (16.1)

 R2

2 (1.7)

 No surgery

30

Number of examined lymph nodes

 Mean

36

 Median

35

 Range

4–88

Differentiation grade

 Low grade

3 (2.4)

 Intermediate grade

52 (42.3)

 High grade

68 (55.3)

 Missing data

25

Lauren classification

 Intestinal

65 (52.8)

 Mixed

16 (13.0)

 Diffuse

42 (34.1)

 Missing data

25

Follow-up resected patients (years)

 Median (95% CI)

5.8 (5.2–6.4)