Table 2 Comparisons of breast milk immune factor concentration with or without sub-clinical mastitis, by HIV group
From: The immune response to sub-clinical mastitis is impaired in HIV-infected women
Immune factor concentration | HIV+ samples | Corrected p-value* | HIV− samples | Corrected p-value* | ||
|---|---|---|---|---|---|---|
No SCM Median [q25–q75] | SCM Median [q25–q75] | No SCM Median [q25–q75] | SCM Median [q25–q75] | |||
Th 1 | ||||||
IL-2R | 65 [20–105] | 82 [66–109] | 0.251 | 66 [20–101] | 166 [66–536] | 0.008 |
IL-12p40/70 | 63 [38–91] | 110 [57–126] | 0.030 | 83 [31–126] | 212 [100–333] | 0.003 |
IL-15 | 47 [32–66] | 77 [49–126] | 0.102 | 30 [13–71] | 100 [27–262] | 0.021 |
MIG | 215 [62–668] | 442 [207–1077] | 0.102 | 79 [10–153] | 1185 [314–1328] | < 0.001 |
IP-10 | 932 [320–1976] | 1913 [557–2653] | 0.102 | 337 [165–519] | 1806 [502–3379] | < 0.001 |
◊ IL-7 | 27 [13–58] | 62 [26–109] | 0.088 | 35 [13–177] | 179 [13–279] | 0.131 |
Anti infl. | ||||||
EPO | 23 [10–31] | 17 [13–33] | 0.970 | 31 [16–40] | 25 [18–33] | 0.920 |
Lactoferrin | 3.8 [2.8–6.6] | 4.5 [2.8–13.8] | 0.598 | 4.8 [2.2–8.7] | 18.8 [2.8–20.2] | 0.136 |
IL-1RA | 326 [131–731] | 430 [232–1203] | 0.183 | 531 [255–905] | 1718 [470–3980] | 0.012 |
Anti bact. response | ||||||
MIP-1α | 23 [8–34] | 34 [24–137] | 0.030 | 20 [8–45] | 145 [20–808] | 0.007 |
MIP-1β | 17 [5–31] | 32 [11–141] | 0.102 | 16 [5–34] | 163 [24–801] | 0.003 |
MCP-1 | 400 [228–1281] | 690 [338–1713] | 0.224 | 524 [240–1221] | 6460 [1994–7200] | 0.003 |
LBP | 63 [43–138] | 248 [97–394] | 0.036 | 84 [54–164] | 357 [85–550] | 0.064 |
sCD14 | 4828 [2479–10,231] | 6573 [2560–9186] | 0.845 | 9059 [5941–18,212] | 27,778 [10,650–57,686] | 0.064 |
SLPI | 20 [13–60] | 40 [32–82] | 0.206 | 35 [14–54] | 102 [55–562] | 0.011 |
Infl. markers | ||||||
RANTES | 72 [45–122] | 151 [88–268] | 0.030 | 87 [51–147] | 238 [110–304] | 0.006 |
CRP | 0.20 [0.10–0.7] | 0.20 [0.10–0.70] | 0.591 | 0.10 [0.10–0.10] | 0.10 [0.10–0.20] | 0.203 |
B2M | 8.5 [7.6–11.0] | 10.1 [8.8–13.0] | 0.088 | 8.1 [7.2–9.3] | 13.6 [10.3–26.8] | < 0.001 |
PS100A9 | 2875 [1405–17,183] | 18,403 [4166–23,934] | 0.088 | 3480 [2235–9930] | 23,129 [8035–25,854] | 0.021 |
IL-8 | 365 [233–1188] | 1275 [503–2803] | 0.030 | 460 [240–844] | 3243 [414–10,160] | 0.007 |