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Table 2 Comparison of glucose levels during 3 h 75 g OGTT and insulin secreting parameters among GDM subgroups and women with NGT

From: Heterogeneity of insulin resistance and beta cell dysfunction in gestational diabetes mellitus: a prospective cohort study of perinatal outcomes

 

GDM-resistance

P value

GDM-dysfunction

P value

GDM-mix

P value

All GDM

P value

NGT

Glucose 0 min (mmol/L)

4.8 (0.6)

0.017

5.1 (0.7)

< 0.001

5.2 (1.0)

< 0.001

5.0 (0.8)

< 0.001

4.6 (0.4)

Glucose 30 min (mmol/L)

8.3 (1.7)

0.008

8.2 (1.4)

< 0.001

9.0 (1.6)

< 0.001

8.5 (1.6)

< 0.001

7.3 (1.5)

Glucose 60 min (mmol/L)

9.8 (2.3)

< 0.001

10.1 (1.9)

< 0.001

10.6 (1.9)

< 0.001

10.2 (2.0)

< 0.001

10.2 (2.0)

Glucose 120 min (mmol/L)

8.6 (2.1)

< 0.001

8.0 (2.8)

< 0.001

9.2 (2.7)

< 0.001

8.6 (2.3)

< 0.001

7.7 (1.9)

Glucose 180 min (mmol/L)

6.1 (2.3)

0.069

6.2 (2.5)

> 0.999

7.5 (2.9)

< 0.001

6.5 (3.0)

< 0.001

6.4 (1.8)

Insulin 0 min (μU/mL)

11.9 (4.9)

< 0.001

7.6 (4.2)

0.628

13.6 (5.9)

< 0.001

10.4 (7.1)

< 0.001

8.3 (5.3)

Insulin 30 min (μU/mL)

106.9 (40.2)

< 0.001

37.0 (27.3)

< 0.001

64.8 (39.9)

> 0.999

59.4 (43.2)

0.356

62.9 (48.9)

Insulin 60 min (μU/mL)

122.0 (61.6)

< 0.001

46.0 (30.2)

0.001

86.2 (48.1)

< 0.001

76.8 (54.9)

0.006

65.0 (46.0)

Insulin 120 min (μU/mL)

126.7 (86.2)

< 0.001

47.9 (38.8)

> 0.999

95.9 (68.0)

< 0.001

77.2 (69.6)

< 0.001

49.3 (53.2)

Insulin 180 min (μU/mL)

63.0 (61.2)

0.003

22.3 (35.5)

> 0.999

67.0 (72.0)

< 0.001

41.5 (59.2)

< 0.001

27.3 (38.2)

HOMA2-IR

1.7 (0.7)

< 0.001

1.2 (0.9)

> 0.999

2.1 (1.1)

< 0.001

1.5 (1.1)

< 0.001

1.2 (0.8)

Matsuda index

2.9 (0.9)

< 0.001

5.4 (1.6)

> 0.999

2.8 (1.2)

< 0.001

3.7 (2.7)

< 0.001

5.6 (3.4)

Insulinogenic index

29.21 (18.5)

< 0.001

9.1 (5.5)

< 0.001

14.4 (9.5)

< 0.001

14.7 (11.5)

< 0.001

21.1 (14.5)

Disposition index

16.0 (9.1)

> 0.999

8.3 (3.4)

< 0.001

7.0 (4.6)

< 0.001

10.3 (8.4)

< 0.001

17.8 (12.1)

GA (%)

11.0 (1.7)

0.017

11.7 (1.9)

> 0.999

11.5 (2.0)

> 0.999

11.6 (2.0)

0.975

11.6 (2.1)

HbA1c (%)

5.2 (0.6)

0.125

5.0 (0.5)

> 0.999

5.2 (0.4)

< 0.001

5.1 (0.4)

< 0.001

5.0 (0.4)

  1. Data are median (IQR) for continuous variables
  2. Differences between GDM subgroups and women with NGT were evaluated with the Kruskal–Wallis test for continuous variables
  3. When the P value was significant (< 0.05), Dunn’s multiple comparisons test was performed to evaluate the difference between each GDM subtype and NGT group. P values for pairwise comparisons were adjusted by Bonferroni correction
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Journal of Translational Medicine

ISSN: 1479-5876

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