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Table 4 Associations of SUA concentration with the severity of Steatosis

From: Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study

SUA levels

Mild-steatosis

Severe-steatosis

 

Cases/n (%)

OR

95% CI

P

Cases/n (%)

OR

95% CI

P

Severity of steatosis (Model 1)

Total (n = 7569)

Q1

72/1419 (5.1)

1

  

104/1451 (7.2)

1

  

Q2

126/1324 (9.5)

2.10

1.55–2.84

< 0.001

212/1410 (15.0)

2.61

2.03–3.34

< 0.001

Q3

180/1228 (14.7)

3.67

2.74–4.92

< 0.001

293/1341 (21.8)

4.81

3.77–6.13

< 0.001

Q4

175/1116 (15.7)

4.16

3.07–5.64

< 0.001

365/1306 (27.9)

7.87

6.16–10.05

< 0.001

Q5

216/1022 (21.1)

6.52

4.78–8.88

< 0.001

486/1292 (37.6)

14.36

11.18–18.46

< 0.001

Men (n = 3126)

Q1

43/548 (7.8)

1

  

55/560 (9.8)

1

  

Q2

77/576 (13.4)

1.76

1.19–2.62

0.005

70/569 (12.3)

1.25

0.86–1.83

0.239

Q3

80/500 (16.0)

2.20

1.48–3.26

< 0.001

117/537 (21.8)

2.51

1.78–3.56

< 0.001

Q4

88/496 (17.7)

2.66

1.80–3.92

< 0.001

133/541 (24.6)

3.14

2.23–4.43

< 0.001

Q5

95/422 (22.5)

3.75

2.54–5.53

< 0.001

209/536 (39.0)

6.44

4.62–8.98

< 0.001

Women (n = 4443)

Q1

31/822 (3.8)

   

51/842 (6.1)

   

Q2

59/788 (7.5)

2.12

1.35–3.31

0.001

93/822 (11.3)

1.99

1.40–2.85

< 0.001

Q3

82/766 (10.7)

3.21

2.09–4.91

< 0.001

144/828 (17.4)

3.31

2.37–4.63

< 0.001

Q4

106/629 (16.9)

5.61

3.69–8.52

< 0.001

249/772 (32.3)

7.57

5.48–10.45

< 0.001

Q5

108/562 (19.2)

6.94

4.55–10.60

< 0.001

339/793 (42.7)

12.06

8.75–16.63

< 0.001

Severity of steatosis (Model 2)

Total (n = 7569)

Q1

72/1419 (5.1)

1

  

104/1451 (7.2)

1

  

Q2

126/1324 (9.5)

1.70

1.24–2.32

0.001

212/1410 (15.0)

1.86

1.39–2.48

< 0.001

Q3

180/1228 (14.7)

2.73

2.01–3.71

< 0.001

293/1341 (21.8)

2.98

2.24–3.96

< 0.001

Q4

175/1116 (15.7)

2.66

1.93–3.67

< 0.001

365/1306 (27.9)

3.71

2.77–4.96

< 0.001

Q5

216/1022 (21.1)

3.48

2.50–4.86

< 0.001

486/1292 (37.6)

5.18

3.83–7.01

< 0.001

Men (n = 3126)

Q1

43/548 (7.8)

1

  

55/560 (9.8)

1

  

Q2

77/576 (13.4)

1.47

0.97–2.22

0.067

70/569 (12.3)

0.95

0.62–1.47

0.815

Q3

80/500 (16.0)

1.67

1.11–2.53

0.015

117/537 (21.8)

1.50

0.99–2.25

0.053

Q4

88/496 (17.7)

1.95

1.30–2.95

0.001

133/541 (24.6)

1.96

1.31–2.93

0.001

Q5

95/422 (22.5)

2.54

1.68–3.84

< 0.001

209/536 (39.0)

2.95

1.99–4.37

< 0.001

Women (n = 4443)

Q1

31/822 (3.8)

1

  

51/842 (6.1)

1

  

Q2

59/788 (7.5)

1.89

1.20–2.98

0.006

93/822 (11.3)

1.58

1.06–2.35

0.025

Q3

82/766 (10.7)

2.42

1.55–3.75

< 0.001

144/828 (17.4)

2.22

1.52–3.24

< 0.001

Q4

106/629 (16.9)

4.02

2.61–6.20

< 0.001

249/772 (32.3)

4.21

2.92–6.05

< 0.001

Q5

108/562 (19.2)

4.17

2.67–6.51

< 0.001

339/793 (42.7)

4.93

3.41–7.12

< 0.001

  1. Category of SUA quintiles
  2. For all participants: Q1, < 231 μmol/L; Q2, 231–271 μmol/L; Q3, 272–312 μmol/L; Q4, 313–366 μmol/L; Q5, ≥ 367 μmol/L
  3. For men: Q1, < 278 μmol/L; Q2, 278–317 μmol/L; Q3, 318–355 μmol/L; Q4, 356–402 μmol/L; Q5, ≥ 403 μmol/L
  4. For women: Q1, < 213 μmol/L; Q2, 213–244 μmol/L; Q3, 245–276 μmol/L; Q4, 277–320 μmol/L; Q5, ≥ 321 μmol/L
  5. Model 1: adjusted for age, sex (only for all participants)
  6. Model 2: adjusted for age, sex (only for all participants), BMI, history of cardiovascular related diseases, DBP, AST, TG, TC, HDL and FPG
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Journal of Translational Medicine

ISSN: 1479-5876

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