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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Upregulation of miR-196b-5p attenuates BCG uptake via targeting SOCS3 and activating STAT3 in macrophages from patients with long-term cigarette smoking-related active pulmonary tuberculosis

Fig. 6

miR-196b-5p inhibited IL-6, TNF-α production on macrophages via activating STAT3 signaling pathway. The supernatant IL-6 (a), TNF-α (b) and IL-10 (c) levels on differentiated U937 cells after exogenously miR-196b-5p, anti-miR-196b-5p transfected were detected by ELISA. And SOCS1, SOCS3, STAT3 and pSTAT3 expression on differentiated U937 cells after exogenously miR-196b-5p, anti-miR-196b-5p transfected were detected by western blotting analysis (d). Data were presented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001

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