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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis

Fig. 5

L4.8 immunization generates long-lasting memory CD4 T cells and CD8 T cells against Mtb. Mice were immunized and splenocytes culture was set as mentioned in the legends to Fig. 4. a Contour plots and their be bar diagrams indicate percentage of CD4 and CD8 gated T cells population expressing central memory (CD62LhiCD44hi) and effector memory (CD62LloCD44hi) phenotype. f Dot plots and their g, h bar diagrams represent percentage population of CD27hiCD43lo CD4 T cells and CD8 T cells. Likewise, i contour plots and j, k bar diagrams indicate percentage of CD4 and CD8 gated T cells (Additional file 2: Fig. S4A) expressing CD127hi population. The data (mean ± SEM) in the inset are percent positive cells and representative of 2 independent experiments (n = 3 mice/group). *p ≤ 0.05, **p ≤ 0.005, ***p ≤ 0.0005, ****p ≤ 0.0001

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