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Table 5 Univariate Cox regression analysis

From: p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Gene name

Beta coefficient

Hazard ratio (95% confidence interval for HR)

p value

CKB

− 0.0621

0.97 (0.819–1.08)

0.376

MUC1

0.181

1.2 (0.944–1.47)

0.0566

FOXM1

0.462

1.59 (1.28–1.96)

1.89E−05

E2F1

0.143

1.15 (1.06–1.25)

0.000551

SFN

0.0768

1.08 (0.983–1.19)

0.111

CKS2

0.408

1.5 (1.19–1.91)

0.000783

CHEK1

0.55

1.73 (1.3–2.31)

0.000165

HSP90AB1

0.494

1.64 (1.25–2.16)

0.000412

RECQL4

0.442

1.56 (1.25–1.94)

8.71E−05

PTTG1

0.397

1.49 (1.18–1.88)

0.000819

AURKA

0.438

1.55 (1.25–1.93)

8.47E−05

PRC1

0.435

1.54 (1.27–1.88)

1.31E−05

HMMR

0.355

1.43 (1.18–1.73)

0.00029

FEN1

0.345

1.41 (1.05–1.91)

0.024

DDIT4

0.348

1.42 (1.16–1.73)

0.000689

MMP2

0.14

1.15 (1.06–1.24)

0.000414

NLRC4

0.109

1.12 (0.844–1.47)

0.443

CDC20

0.361

1.43 (1.21–1.71)

4.61E−05

RAS

0.32

1.38 (1.11–1.71)

0.0039

PLAUR

0.185

1.2 (0.98–1.48)

0.0779

MCTS1

0.542

1.72 (1.09–2.71)

0.0194

GAPDH

0.119

1.13 (0.86–1.47)

0.388

ECT2

0.49

1.63 (1.3–2.04)

1.87E−05

EZH2

0.184

1.2 (1.09–1.33)

0.000268

APAF1

0.443

1.56 (1.15–2.1)

0.00383

BRCA1

0.203

1.22 (1.11–1.35)

6.32E−05

HIF1A

0.146

1.16 (1.01–1.33)

0.0404

MAPK14

0.139

1.15 (0.803–1.64)

0.447

NCL

0.504

1.66 (1.13–2.43)

0.00978

SIAH1

0.143

1.15 (0.974–1.37)

0.0986

  1. The Cox regression results for genes listed in the Table 4 are shown in the Table 5. The column of beta coefficient shows the beta regression coefficient. The column of HR [95% confidence intervals (CI) for HR] list the hazard ratios (the exponentiated coefficients) and the size of the confidence intervals of the hazard ratios. The column of p value lists the p value for the Wald test method