Skip to main content

Table 5 Stratification analysis of polymorphism genotypes associated with EBC survival

From: Subtype-specific associations between breast cancer risk polymorphisms and the survival of early-stage breast cancer

SNPs

Variables

iDFS

DDFS

BCSS

OS

Adjusted HR (95% CI)

P valuea

Adjusted HR (95% CI)

P valuea

Adjusted HR (95% CI)

P valuea

Adjusted HR (95% CI)

P valuea

rs4415084

Age at diagnosis

        

 ≤ 35

1.792 (1.161–2.915)

0.068

2.172 (1.310–3.602)

0.014

2.250 (1.278–3.959)

0.018

1.871 (0.988–3.544)

0.009

 > 35

1.073 (0.830–1.386)

 

1.056 (0.809–1.379)

 

1.067 (0.796–1.431)

 

0.743 (0.584–0.946)

 

rs2046210

Tumor size (cm)

        

 ≤ 2

1.277 (0.791–2.061)

0.052

1.277 (0.773–2.109)

0.048

1.558 (0.874–2.780)

0.015

1.522 (0.867–2.670)

0.012

 > 2

0.757 (0.606–0.944)

 

0.732 (0.582–0.919)

 

0.713 (0.553–0.920)

 

0.694 (0.540–0.992)

 

rs2981582

Grade

        

 I + II

0.922 (0.642–1.323)

0.048

0.791 (0.532–1.177)

0.017

0.822 (0.529–1.278)

0.023

0.872 (0.571–1.331)

0.040

 III

1.666 (1.051–2.639)

 

1.682 (1.049–2.698)

 

1.783 (1.080–2.944)

 

1.732 (1.050–2.855)

 

rs3803662

Grade

        

 I + II

1.017 (0.812–1.273)

0.010

1.096 (0.866–1.387)

0.005

1.151 (0.884–1.500)

0.000

1.075 (0.830–1.392)

0.001

 III

0.588 (0.414–0.834)

 

0.586 (0.407–0.845)

 

0.479 (0.319–0.717)

 

0.484 (0.324–0.722)

 
  1. Adjusted for age at diagnosis, tumor size, lymph node involvement, grade, hormone receptor, HER2 status, exception for stratification factor
  2. HR hazard risk, CI confidence interval
  3. aHeterogeneity test for differences between groups