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Table 4 Cumulative effect of unfavorable genotypes in luminal B subtype breast cancer

From: Subtype-specific associations between breast cancer risk polymorphisms and the survival of early-stage breast cancer

Number of risk genotypesa

Cases

iDFS

DDFS

BCSS

OS

Events

Adjusted HR (95% CI)b

P value

Events

Adjusted HR (95% CI)b

P value

Events

Adjusted HR (95% CI)b

P value

Events

Adjusted HR (95% CI)b

P value

0–1

165

49

1 (reference)

 

42

1 (reference)

 

32

1 (reference)

 

33

1 (reference)

 

2

272

123

1.912 (1.369–2.670)

1.44 × E−4

109

1.894 (1.324–2.711)

4.74 × E−4

81

1.787 (1.184–2.697)

5.70 × E−3

84

1.786 (1.192–6.678)

4.97 × E−3

3

137

68

2.431 (1.679–3.519)

2.52 × E−6

67

2.744 (1.862–4.043)

3.53 × E−7

50

2.525 (1.617–3.943)

4.61 × E−5

55

2.755 (1.786–4.251)

4.59 × E−6

Trend P

  

1.534 (1.288–1.827)

1.63 × E−6

 

1.632 (1.356–1.964)

2.18 × E−7

 

1.570 (1.267–1.944)

3.66 × E−5

 

1.645 (1.334–2.029)

3.25 × E−6

  1. ars4951011 AA, rs889312 CC + CA and rs9485372 GA + AA were presumed as unfavorable genotypes
  2. bHR hazard risk, CI confidence interval; Adjusted for age at diagnosis, tumor size, lymph node involvement, grade