Subtype-specific associations between breast cancer risk polymorphisms and the survival of early-stage breast cancer

Table 1 Patients’ clinicopathological characteristics and clinical outcome

Variables	Patients N = 1177	iDFS		DDFS		BCSS		OS
Variables	Patients N = 1177	Events	LogRank P	Events	LogRank P	Events	LogRank P	Events	LogRank P
Age at diagnosis			0.021		0.087		0.420		0.402
≤ 35	184	85		76		59		61
> 35	993	361		334		274		282
Tumor size (cm)			< 0.001		< 0.001		< 0.001		< 0.001
≤ 2	403	88		80		67		70
> 2	774	358		330		266		273
Nodal status			< 0.001		< 0.001		< 0.001		< 0.001
Negative	510	116		101		69		75
Positive	667	330		309		264		268
Clinical stage			< 0.001		< 0.001		< 0.001		< 0.001
I	257	40		35		29		31
II + III	920	406		375		304		312
Grade^a			< 0.001		< 0.001		< 0.001		< 0.001
I + II	904	310		286		228		236
III	271	134		122		103		105
ER			< 0.001		< 0.001		< 0.001		< 0.001
Negative	378	177		165		149		150
Positive	799	269		245		184		193

Variables	Patients N = 1177	iDFS	DDFS	BCSS	OS	iDFS	DDFS	BCSS	OS
Variables	Patients N = 1177	Events	LogRank P	Events	LogRank P	Events	LogRank P	Events	LogRank P
PR			< 0.001		< 0.001		< 0.001		< 0.001
Negative	367	171		159		144		145
Positive	810	275		251		189		198
HER2			< 0.001		< 0.001		< 0.001		< 0.001
Negative	860	292		268		214		222
Positive	317	154		142		119		121
Subtype			< 0.001		< 0.001		< 0.001		< 0.001
Luminal A	236	35		33		26		26
Luminal B	574	240		218		163		172
HER2+	160	80		76		67		67
Triple negative	207	91		83		77		78

ISSN: 1479-5876