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Table 3 Gene ontology clustering on genes correlated with MUC4 expression

From: Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas

Enrichment score

Gene ontology terms and annotations

Count

p value

7.08

Cell–cell adherens junction

18

1.4E−08

Cadherin binding involved in cell–cell adhesion

17

2.0E−08

Cell–cell adhesion

14

2.2E−06

5.44

Tight junction

10

6.6E−08

Bicellular tight junction

10

1.4E−06

Tight junction

9

8.1E−06

Bicellular tight junction assembly

5

2.4E−04

4.67

Pleckstrin homology-like domain

17

2.6E−06

Pleckstrin homology domain

13

9.3E−06

Domain: PH

11

8.0E−05

PH

12

1.1E−04

3.35

SH2 domain

8

9.1E−05

Domain: SH2

7

2.3E−04

SH2 domain

7

3.9E−04

SH2

6

4.8E−03

3.34

Glycoprotein

64

6.0E−05

Glycosylation site: N-linked (GlcNAc…)

61

1.1E−04

Disulfide bond

44

6.4E−04

Signal peptide

48

9.7E−04

Disulfide bond

48

9.8E−04

Signal

54

2.2E−03

2.76

Topological domain: cytoplasmic

53

8.1E−05

Membrane

91

1.6E−04

Transmembrane region

66

8.5E−04

Topological domain: extracellular

42

9.2E−04

Transmembrane helix

66

7.2E−03

Transmembrane

66

7.7E−03

Integral component of membrane

59

8.4E−02

2.6

Domain: SH3

9

1.9E−04

SH3 domain

9

6.5E−04

Src homology-3 domain

8

4.4E−03

SH3

6

6.9E−02

2.48

Signal peptide

48

9.7E−04

Secreted

31

2.0E−03

Extracellular region

25

1.9E−02

2.43

Establishment of protein localization to plasma membrane

6

4.9E−05

Cell adhesion molecule binding

5

3.0E−03

Actin cytoskeleton

4

3.5E−01

2.32

Extracellular matrix organization

10

1.2E−04

Epidermolysis bullosa, junctional, non-Herlitz type

3

2.8E−04

Epidermolysis bullosa

4

2.8E−04

Hemidesmosome assembly

3

5.7E−03

ECM-receptor interaction

4

2.9E−02

Focal adhesion

5

7.2E−02

PI3K-Akt signaling pathway

4

5.0E−01

2.19

Serine protease

8

2.5E−04

Peptidase S1, trypsin family, active site

7

3.9E−04

Domain: peptidase S1

7

4.7E−04

Active site: charge relay system

9

5.3E−04

Peptidase S1

7

9.1E−04

Trypsin-like cysteine/serine peptidase domain

7

1.3E−03

Tryp_SPc

7

1.6E−03

Extrinsic component of plasma membrane

4

1.7E−03

Peptidase S1A, chymotrypsin-type

6

4.1E−03

Serine-type endopeptidase activity

8

1.2E−02

Serine-type peptidase activity

4

2.3E−02

Protease

8

2.0E−01

Zymogen

4

2.9E−01

Proteolysis

7

3.5E−01

Hydrolase

13

8.1E−01

1.74

CP2 transcription factor

3

1.3E−03

Region of interest: transcription activation

3

3.5E−03

Chromatin DNA binding

3

1.1E−01

Sequence-specific DNA binding

8

2.3E−01

1.69

O-glycan processing

6

2.7E−04

Glycosphingolipid biosynthesis—lacto and neolacto series

4

9.8E−04

Protein glycosylation

6

4.7E−03

Glycosyltransferase

7

1.8E−02

Topological domain: lumenal

10

2.1E−02

Golgi cisterna membrane

4

3.6E−02

Signal-anchor

9

4.8E−02

Golgi apparatus

12

1.0E−01

Golgi membrane

9

2.0E−01

Metabolic pathways

9

7.5E−01

1.51

Rho guanyl-nucleotide exchange factor activity

5

6.4E−03

Regulation of Rho protein signal transduction

5

7.6E−03

Dbl homology (DH) domain

4

2.9E−02

Domain: DH

3

1.3E−01

RhoGEF

3

1.6E−01

  1. Gene list was retrieved from 881 samples of Cancer Cell Line Encyclopedia (Baretina, Nature 2012). 187 genes that are positively (n = 178) or negatively (n = 9) correlated with MUC4 expression were selected. Functional Annotation and gene clustering were performed using David Functional Annotation Tool (https://david.ncifcrf.gov/)