Sex-specific associations between telomere length and candidate miRNA expression in placenta

Tsamou, Maria; Martens, Dries S.; Cox, Bianca; Madhloum, Narjes; Vrijens, Karen; Nawrot, Tim S.

doi:10.1186/s12967-018-1627-z

Journal of Translational Medicine

Table 3 Associations of placental relative telomere length (RTL) with placental relative miRNA expression, in newborn girls (n = 105) and boys (98)

From: Sex-specific associations between telomere length and candidate miRNA expression in placenta

miRNAs	Unadjusted analysis		Main analysis^a		Sensitivity analysis
	Unadjusted analysis		Main analysis^a		Model 1^b		Model 2^c		Model 3^d
	% Change in RTL (95% CI)	p-value	% Change in RTL (95% CI)	p-value	% Change in RTL (95% CI)	p-value	% Change in RTL (95% CI)	p-value	% Change in RTL (95% CI)	p-value
Girls
miR-16	2.38 (− 0.15, 4.96)	0.068	1.93 (− 0.88, 4.82)	0.18	2.38 (− 0.53, 5.37)	0.11	2.02 − 0.86, 4.98)	0.17	2.42 (− 0.45, 5.38)	0.10
miR-20a	2.56 (− 0.13, 5.31)	0.065	2.14 (− 0.78, 5.14)	0.16	2.52 (− 0.47, 5.60)	0.10	2.28 (− 0.73, 5.38)	0.14	3.22 (0.14, 6.39)	0.044
miR-21	1.10 (− 1.04, 3.30)	0.32	0.78 (− 1.55, 3.17)	0.52	1.39 (− 1.06, 3.89)	0.27	0.82 (− 1.56, 3.26)	0.50	1.22 (− 1.18, 3.67)	0.33
miR-34a	2.60 (0.60, 4.64)	0.012*	2.84 (0.67, 5.05)	0.012*	3.05 (0.78, 5.37)	0.010*	2.96 (0.68, 5.29)	0.012*	3.22 (1.04, 5.45)	0.005*
miR-146a	3.57 (0.98, 6.22)	0.008*	3.44 (0.70, 6.26)	0.016*	3.48 (0.68, 6.37)	0.017*	3.55 (0.74, 6.44)	0.015*	3.95 (1.17, 6.81)	0.006*
miR-210	2.70 (0.67, 4.77)	0.010*	2.51 (0.28, 4.79)	0.030*	2.73 (0.40, 5.10)	0.024*	2.60 (0.31, 4.94)	0.028*	2.77 (0.53, 5.06)	0.017*
miR-222	4.05 (1.29, 6.89)	0.005*	3.61 (0.58, 6.74)	0.022*	3.99 (0.79, 7.30)	0.016*	3.74 (0.63, 6.94)	0.020*	4.73 (1.57, 7.99)	0.004*
Boys
miR-16	0.09 (− 2.76, 3.04)	0.95	− 1.15 (− 3.99, 1.78)	0.44	− 1.85 (− 4.60, 0.98)	0.21	− 1.32 (− 4.16, 1.61)	0.37	− 1.43 (− 4.34, 1.56)	0.35
miR-20a	− 0.50 (− 3.27, 2.36)	0.73	− 0.55 (− 3.27, 2.26)	0.70	− 1.20 (− 3.84, 1.52)	0.39	− 0.73 (− 3.48, 2.09)	0.61	− 1.05 (− 3.86, 1.85)	0.48
miR-21	− 2.03 (− 4.47, 0.49)	0.12	− 2.20 (− 4.62, 0.28)	0.085	− 2.48 (− 4.78, − 0.12)	0.043	− 2.22 (− 4.64, 0.26)	0.082	− 2.44 (− 4.89, 0.08)	0.061
miR-34a	0.59 (− 1.83, 3.07)	0.64	− 0.93 (− 3.41, 1.61)	0.47	− 1.39 (− 3.82, 1.09)	0.27	− 1.10 (− 3.58, 1.45)	0.40	− 1.45 (− 3.95, 1.10)	0.27
miR-146a	− 0.23 (− 3.24, 2.88)	0.89	− 0.32 (− 3.37, 2.83)	0.84	− 0.58 (− 3.58, 2.51)	0.71	− 0.50 (− 3.56, 2.65)	0.75	− 1.14 (− 4.30, 2.12)	0.49
miR-210	− 0.08 (− 2.28, 2.17)	0.94	− 0.03 (− 2.26, 2.25)	0.98	− 0.89 (− 3.05, 1.32)	0.43	− 0.31 (− 2.57, 2.01)	0.79	− 0.38 (− 2.62, 1.92)	0.75
miR-222	0.40 (− 2.74, 3.64)	0.81	− 0.85 (− 3.91, 2.31)	0.60	− 1.08 (− 4.06, 1.99)	0.49	− 1.28 (− 4.37, 1.91)	0.43	− 1.97 (− 5.20, 1.38)	0.25

Estimated effects are presented with the obtained % change (95% CI) in placental RTL for a doubling in miRNA expression
*Remained significant after FDR correction (FDR ≤ 0.05)
^aMain analysis was adjusted for newborn’s ethnicity, gestational age, paternal age, maternal smoking status, maternal educational status, parity, date of delivery and outdoor temperature during the 3rd trimester of pregnancy
^bExcluding newborns with non-European ethnicity (girls: n = 98, boys: n = 88)
^cMain analysis was additionally adjusted for pre-pregnancy BMI and gestational weight gain during pregnancy
^dMain analysis was additionally adjusted for trimester-specific PM_2.5 air pollution

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