Table 4 Fold change, t-test statistics, and area under the curve (AUC) of the receiver operating curves (ROC) for 24 amino acids, free carnitine and acylcarnitines (p < 0.05)
MPSIIIA vs control | MPSIIIB vs control | MPSIIIC vs control | MPSIIID vs control | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
AUC | q-value (FDR) | Fold change | AUC | q-value (FDR) | Fold change | AUC | q-value (FDR) | Fold change | AUC | q-value (FDR) | Fold change | |
l -Arginine | 0.98 | 7.77E−09 | − 4.53 | 0.98 | 1.45E−10 | − 3.90 | 0.95 | 4.26E−06 | − 3.60 | 0.98 | 1.08E−04 | − 3.75 |
l -Aspartic acid | 0.95 | 2.10E−09 | − 3.83 | 0.94 | 1.29E−10 | − 3.30 | 0.77 | 1.43E−02 | − 1.45 | 0.56 | 6.06E−01 | 0.30 |
l -Alanine | 0.86 | 1.32E−03 | − 1.11 | 0.87 | 1.81E−04 | − 0.45 | 0.67 | 2.55E−01 | − 0.33 | 0.81 | 4.63E−02 | − 0.50 |
l -Threonine | 0.81 | 8.18E−03 | − 1.13 | 0.86 | 2.68E−04 | − 0.72 | 0.50 | 2.86E−01 | 0.91 | 0.78 | 4.63E−02 | − 0.61 |
l -Histidine | 0.77 | 1.76E−02 | − 0.98 | 0.81 | 1.60E−03 | − 0.43 | 0.59 | 5.02E−01 | − 0.11 | 0.69 | 2.89E−01 | − 0.09 |
l -Phenylalanine | 0.76 | 2.82E−02 | − 0.78 | 0.77 | 6.94E−02 | 0.08 | 0.52 | 4.02E−01 | 0.67 | 0.63 | 2.89E−01 | − 0.03 |
Glycine | 0.75 | 1.76E−02 | − 0.82 | 0.78 | 3.34E−03 | − 0.13 | 0.63 | 4.09E−01 | − 0.12 | 0.81 | 2.27E−02 | − 0.69 |
l -Proline | 0.73 | 5.17E−02 | − 0.69 | 0.77 | 3.93E−03 | − 0.16 | 0.52 | 6.61E−01 | 0.44 | 0.71 | 2.89E−01 | 0.03 |
l -Glutamine | 0.73 | 1.98E−01 | − 0.46 | 0.87 | 1.04E−03 | − 0.49 | 0.55 | 4.02E−01 | 0.77 | 0.72 | 4.63E−02 | − 0.52 |
l -Asparagine | 0.72 | 7.76E−02 | − 0.69 | 0.83 | 1.48E−03 | − 0.51 | 0.55 | 6.61E−01 | 0.46 | 0.70 | 1.67E−01 | − 0.30 |
l -Tyrosine | 0.71 | 6.88E−02 | − 0.63 | 0.80 | 4.01E−03 | − 0.21 | 0.50 | 2.86E−01 | 0.89 | 0.64 | 2.97E−01 | 0.04 |
l-Tryptophan | 0.70 | 1.19E−01 | − 0.49 | 0.74 | 2.59E−01 | 0.36 | 0.58 | 1.29E−01 | 1.13 | 0.55 | 5.60E−01 | 0.44 |
l -Leucine | 0.67 | 1.84E−01 | − 0.49 | 0.79 | 2.31E−02 | − 0.08 | 0.64 | 2.55E−01 | 0.93 | 0.62 | 3.62E−01 | 0.08 |
Taurine | 0.66 | 1.84E−01 | − 0.71 | 0.52 | 8.38E−01 | 0.73 | 0.56 | 9.70E−01 | 0.27 | 0.55 | 6.53E−01 | 1.12 |
l -Serine | 0.65 | 4.20E−01 | − 0.44 | 0.78 | 1.01E−01 | − 0.20 | 0.63 | 8.53E−02 | 1.89 | 0.68 | 3.73E−01 | − 0.22 |
l-Glutamic acid | 0.62 | 1.34E−01 | − 0.48 | 0.55 | 8.23E−01 | 0.78 | 0.52 | 2.86E−01 | 0.76 | 0.52 | 5.37E−01 | 1.12 |
l-Lysine | 0.61 | 3.99E−01 | − 0.43 | 0.65 | 2.01E−01 | 0.10 | 0.59 | 3.72E−01 | 0.88 | 0.66 | 4.09E−01 | 0.02 |
l -Isoleucine | 0.61 | 7.85E−01 | − 0.02 | 0.67 | 2.51E−01 | 0.36 | 0.68 | 4.42E−02 | 1.35 | 0.59 | 4.09E−01 | 0.18 |
l-Valine | 0.60 | 6.68E−01 | − 0.10 | 0.70 | 2.64E−01 | 0.36 | 0.66 | 2.55E−01 | 0.99 | 0.58 | 4.09E−01 | 0.15 |
l-Ornithine | 0.60 | 2.65E−01 | − 1.01 | 0.53 | 8.53E−01 | 0.70 | 0.61 | 2.86E−01 | 1.53 | 0.53 | 6.53E−01 | 1.31 |
l-Cystine | 0.59 | 6.68E−01 | − 0.19 | 0.71 | 1.01E−01 | − 0.08 | 0.51 | 9.70E−01 | 0.32 | 0.69 | 2.89E−01 | − 0.38 |
Cystathionine | 0.55 | 9.48E−01 | 0.25 | 0.60 | 5.76E−01 | 1.36 | 0.63 | 9.70E−01 | 0.25 | 0.53 | 5.60E−01 | 0.09 |
l -Methionine | 0.54 | 9.48E−01 | 0.11 | 0.51 | 9.71E−01 | 0.83 | 0.79 | 3.29E−03 | 2.15 | 0.69 | 3.62E−01 | 1.60 |
l -Citrulline | 0.52 | 8.20E−01 | 0.03 | 0.60 | 6.61E−01 | 0.54 | 0.74 | 9.43E−03 | 2.11 | 0.76 | 7.15E−02 | 2.48 |