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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

Fig. 3

Mice were subjected to OVA sensitization followed by a single challenge or left unchallenged. Mice were administered, i.p., 10 mg/kg S-NACH or saline 30 min after OVA challenge. Mice were then sacrificed 48 h later and lungs were subjected to formalin fixation or BAL. a Cells of BALF were differentially stained, and total cells, eosinophils, macrophages, and lymphocytes were counted. Data are expressed as total number of cells per mouse. Data are mean ± SD of values from at least 6 mice per group. b Lung sections from OVA-challenged mice that were treated with either saline or S-NACH were subjected to PAS staining; Bar = 50 μm. BALF (c) and sera (d) collected from the different mouse groups were assessed for different Th1 and Th2 cytokines using a multiplex assay. e BALF and sera were assessed for OVA-specific IgE with ELISA. Data are mean ± SD of values from at least 6 mice per group. For (a), (c), (d), and e *difference from control unchallenged mice, p < 0.05; #difference from OVA-challenged mice; p < 0.05

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