TY - JOUR AU - Ramos-Peñafiel, Christian AU - Olarte-Carrillo, Irma AU - Cerón-Maldonado, Rafael AU - Rozen-Fuller, Etta AU - Kassack-Ipiña, Juan Julio AU - Meléndez-Mier, Guillermo AU - Collazo-Jaloma, Juan AU - Martínez-Tovar, Adolfo PY - 2018 DA - 2018/09/03 TI - Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene JO - Journal of Translational Medicine SP - 245 VL - 16 IS - 1 AB - In acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies have shown an anti-cancer effect of metformin. Therefore, the objective of this study was to assess the effect of metformin on the treatment regimen in patients with ALL who exhibited high levels of ABCB1 gene expression and to determine its impact on overall survival. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-018-1620-6 DO - 10.1186/s12967-018-1620-6 ID - Ramos-Peñafiel2018 ER -