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Table 2 Associations between IgG glycan and blood lipids

From: The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

IgG glycans

Prin. 3

Prin. 4

β (95% CI)a

P

β (95% CI)b

P

Initial measurements

 GP2

0.046 (0.006 to 0.087)

0.023*

− 0.012 (− 0.055 to 0.032)

0.596

 GP4

0.035 (0.014 to 0.056)

0.001*

− 0.015 (− 0.039 to 0.010)

0.237

 GP5

0.035 (0.014 to 0.055)

0.001*

0.019 (− 0.006 to 0.044)

0.130

 GP6

0.036 (0.015 to 0.057)

< 0.001**

− 0.010 (− 0.034 to 0.014)

0.395

 GP11

0.020 (0.004 to 0.036)

0.013*

0.017 (− 0.001 to 0.035)

0.066

 GP14

− 0.022 (− 0.037 to 0.006)

0.006*

0.004 (− 0.014 to 0.022)

0.642

 GP18

− 0.033 (− 0.051 to 0.015)

< 0.001**

0.006 (− 0.015 to 0.026)

0.604

 GP20

0.014 (− 0.015 to 0.042)

0.336

0.051 (0.018 to 0.084)

0.003*

 GP21

0.024 (0.004 to 0.045)

0.020*

0.025 (0.001 to 0.049)

0.041*

Sialylation

 FGS/(FG + FGS)

− 0.014 (− 0.025 to 0.003)

0.013*

0.001 (− 0.011 to 0.014)

0.840

 FGS/(F + FG + FGS)

− 0.023 (− 0.037 to 0.008)

0.003*

0.006 (− 0.012 to 0.023)

0.527

Bisecting GlcNAc

 FBStotal/FStotal

0.021 (0.002 to 0.041)

0.032*

− 0.008 (− 0.030 to 0.014)

0.498

 FBS2/FS2

0.020 (0.001 to 0.038)

0.039*

0.005 (− 0.016 to 0.023)

0.660

 FBS2/(FS2 + FBS2)

0.011 (0.001 to 0.020)

0.034*

0.002 (− 0.009 to 0.013)

0.740

Galactosylation

 G0n

0.029 (0.012 to 0.046)

0.001*

–0.013 (− 0.033 to 0.007)

0.212

 G2n

− 0.026 (− 0.043 to 0.009)

0.003*

0.008 (− 0.013 to 0.027)

0.476

  1. Prin.1 = 0.773 × SBP + 0.783 × DBP + 0.575 × FBG + 0.106 × RHR + 0.352 × Age + 0.688 × BMI + 0.733 × WHR
  2. Prin.2 = 0.361 × SBP + 0.364 × DBP − 0.176 × FBG + 0.739 × RHR − 0.370 × Age − 0.246 × BMI − 0.329 × WHR
  3. Prin.3 = 0.985 × TC + 0.134 × TG + 0.444 × HDL + 0.923 × LDL
  4. Prin.4 = 0.133 × TC + 0.889 × TG-0.755 × HDL + 0.092 × LDL
  5. BMI body mass index, WHR waist–hip ratio, FBG fasting blood glucose, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG total triglycerides, HDL high-density lipoprotein, LDL low-density lipoprotein, RHR resting heart rate
  6. aAdjusted for the effects of sex, Prin.1, Prin.2 and Prin.4
  7. bAdjusted for the effects of sex, Prin.1, Prin.2 and Prin.3
  8. * Statistically significant associations between two variables are shown, P < 0.05
  9. ** Statistically significant associations between two variables are shown, P < 0.05/57 = 0.0009