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Table 2 Associations between IgG glycan and blood lipids

From: The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

IgG glycans Prin. 3 Prin. 4
β (95% CI)a P β (95% CI)b P
Initial measurements
 GP2 0.046 (0.006 to 0.087) 0.023* − 0.012 (− 0.055 to 0.032) 0.596
 GP4 0.035 (0.014 to 0.056) 0.001* − 0.015 (− 0.039 to 0.010) 0.237
 GP5 0.035 (0.014 to 0.055) 0.001* 0.019 (− 0.006 to 0.044) 0.130
 GP6 0.036 (0.015 to 0.057) < 0.001** − 0.010 (− 0.034 to 0.014) 0.395
 GP11 0.020 (0.004 to 0.036) 0.013* 0.017 (− 0.001 to 0.035) 0.066
 GP14 − 0.022 (− 0.037 to 0.006) 0.006* 0.004 (− 0.014 to 0.022) 0.642
 GP18 − 0.033 (− 0.051 to 0.015) < 0.001** 0.006 (− 0.015 to 0.026) 0.604
 GP20 0.014 (− 0.015 to 0.042) 0.336 0.051 (0.018 to 0.084) 0.003*
 GP21 0.024 (0.004 to 0.045) 0.020* 0.025 (0.001 to 0.049) 0.041*
Sialylation
 FGS/(FG + FGS) − 0.014 (− 0.025 to 0.003) 0.013* 0.001 (− 0.011 to 0.014) 0.840
 FGS/(F + FG + FGS) − 0.023 (− 0.037 to 0.008) 0.003* 0.006 (− 0.012 to 0.023) 0.527
Bisecting GlcNAc
 FBStotal/FStotal 0.021 (0.002 to 0.041) 0.032* − 0.008 (− 0.030 to 0.014) 0.498
 FBS2/FS2 0.020 (0.001 to 0.038) 0.039* 0.005 (− 0.016 to 0.023) 0.660
 FBS2/(FS2 + FBS2) 0.011 (0.001 to 0.020) 0.034* 0.002 (− 0.009 to 0.013) 0.740
Galactosylation
 G0n 0.029 (0.012 to 0.046) 0.001* –0.013 (− 0.033 to 0.007) 0.212
 G2n − 0.026 (− 0.043 to 0.009) 0.003* 0.008 (− 0.013 to 0.027) 0.476
  1. Prin.1 = 0.773 × SBP + 0.783 × DBP + 0.575 × FBG + 0.106 × RHR + 0.352 × Age + 0.688 × BMI + 0.733 × WHR
  2. Prin.2 = 0.361 × SBP + 0.364 × DBP − 0.176 × FBG + 0.739 × RHR − 0.370 × Age − 0.246 × BMI − 0.329 × WHR
  3. Prin.3 = 0.985 × TC + 0.134 × TG + 0.444 × HDL + 0.923 × LDL
  4. Prin.4 = 0.133 × TC + 0.889 × TG-0.755 × HDL + 0.092 × LDL
  5. BMI body mass index, WHR waist–hip ratio, FBG fasting blood glucose, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG total triglycerides, HDL high-density lipoprotein, LDL low-density lipoprotein, RHR resting heart rate
  6. aAdjusted for the effects of sex, Prin.1, Prin.2 and Prin.4
  7. bAdjusted for the effects of sex, Prin.1, Prin.2 and Prin.3
  8. * Statistically significant associations between two variables are shown, P < 0.05
  9. ** Statistically significant associations between two variables are shown, P < 0.05/57 = 0.0009