Fig. 1
From: Large-scale in silico identification of drugs exerting sex-specific effects in the heart
The framework for an in silico prediction model of sex-biased drug responses. The in silico pipeline first identified sex-biased genes in healthy cardiac tissues from a GEO public gene expression dataset (a). Then the pipeline build associations between sex-biased genes from the GEO dataset and drug-deregulated genes from the Connectivity Map database. The drugs with significant associations with the heart sex-biased genes will be predicted to have sex-biased effects on human heart. Top 20 predictions (b)