Table 3 Baseline serum cytokine levels grouped by their clinical course resp. treatment
Serum cytokine levels (mean ± SD, pg/mL) | EV persistence (n = 23) | EV clearance (n = 42) | EV persistence + IFN-β (n = 32) | ANOVA p value all 3 groups | Student’s t-test p value persistence vs. clearance |
|---|---|---|---|---|---|
IL-1β | 3.90 ± 7.61 | 6.72 ± 12.72 | 1.41 ± 3.20 | 0.174 | 0.405 |
IL-4 | 1.03 ± 2.99 | 3.43 ± 11.51 | 0.89 ± 1.97 | 0.448 | 0.393 |
IL-5 | 0.52 ± 0.51 | 0.98 ± 2.93 | 1.76 ± 3.30 | 0.347 | 0.521 |
IL-6 | 55.46 ± 64.38 | 58.57 ± 96.80 | 35.25 ± 30.62 | 0.530 | 0.906 |
IL-7 | 1.55 ± 1.31 | 4.22 ± 8.76 | 3.33 ± 3.77 | 0.356 | 0.208 |
IL-8 | 9.70 ± 11.11 | 5.63 ± 8.68 | 3.98 ± 3.01 | 0.099 | 0.180 |
IL-10 | 3.81 ± 2.85 | 6.38 ± 11.33 | 6.98 ± 10.08 | 0.557 | 0.365 |
IL-12 (p70) | 1.31 ± 2.51 | 4.27 ± 10.01 | 10.81 ± 39.17 | 0.430 | 0.228 |
IL-13 | 1.09 ± 1.64 | 10.67 ± 48.17 | 2.26 ± 5.01 | 0.525 | 0.406 |
IL-17 | 4.07 ± 6.11 | 3.86 ± 8.21 | 2.69 ± 5.17 | 0.787 | 0.927 |
G-CSF | 13.91 ± 14.63 | 17.78 ± 28.28 | 9.70 ± 8.95 | 0.413 | 0.597 |
GM-CSF | 24.96 ± 38.32 | 71.73 ± 140.00 | 22.61 ± 33.09 | 0.339 | 0.314 |
IFNγ | 63.81 ± 182.41 | 49.97 ± 87.50 | 11.9 ± 13.14 | 0.386 | 0.485 |
MCP-1 (MCAF) | 42.90 ± 66.10 | 67.85 ± 163.90 | 24.55 ± 10.85 | 0.418 | 0.545 |
MIP-1β | 37.66 ± 28.71 | 42.56 ± 55.97 | 30.30 ± 12.75 | 0.583 | 0.735 |
TNFα | 5.81 ± 14.98 | 8.57 ± 17.14 | 5.22 ± 13.03 | 0.740 | 0.589 |