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Table 1 Univariate and multivariate Cox regression models for progression-free survival (PFS) (N = 83)

From: Coexisting YAP expression and TP53 missense mutations delineates a molecular scenario unexpectedly associated with better survival outcomes in advanced gastric cancer

 

N (%)

Univariate Cox regression model

Multivariate Cox regression model

HR (95% CI)

p-value

HR (95% CI)

p-value

YAP+/TP53mut(mv)

Positive vs negative

27 (32.5%) vs 56 (67.5%)

0.58 (0.34–0.98)

0.040

0.53 (0.30–0.91)

0.022

ECOG-PS

1–2 vs 0

39 (47.0%) vs 44 (53.0%)

1.27 (0.79–2.04)

0.325

1.21 (0.74–1.98)

0.439

Stage

Metastatic vs locally advanced

47 (56.6%) vs 36 (43.4%)

1.24 (0.77–1.99)

0.384

1.48 (0.84–2.59)

0.171

Localization

Stomach vs EOJ

76 (91.6%) vs 7 (8.4%)

0.68 (0.29–1.59)

0.376

0.61 (0.23–1.61)

0.317

No. metastatic sites

2–3 vs 1

25 (30.1%) vs 58 (69.9%)

1.41 (0.83–2.37)

0.199

1.20 (0.67–2.15)

0.541

Taxanes

Yes vs no

44 (53.0%) vs 39 (47.0%)

0.81 (0.50–1.31)

0.395

0.73 (0.42–1.28)

0.274