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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

Fig. 5

GSK872 inhibited LPS induced activation of NLRP3 pathway in THP-1 cells. a Representative western blot bands showed the protein expression of NLRP3, Caspase-1, Caspase-1p20 and GAPDH. b Quantitative data showed protein expressions of NLRP3 and caspase-1p20 normalized to the values of GAPDH and caspase-1 respectively. c Representative flow-cytometric histograms of active caspase-1 expression in THP-1 cell treated by PBS (grey line), LPS + ATP (red line) and LPS + ATP + GSK872 (blue line). d IL-1β and IL-18 level in supernatants from THP-1 cells determined by ELISA. Each bar represents mean ± SEM (n = 4). *p < 0.05, **p < 0.01 versus PBS group; #p < 0.05, ##p < 0.01 versus LPS + ATP group

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