| |
BP category
|
Model 1
|
Model 2
|
|---|
| |
E/N
|
HR
|
(95% CI)
|
p
|
HR
|
(95% CI)
|
p
|
|---|
|
Total (N = 1448)
|
SBP < 120
|
41/413
|
1.01
|
(0.64–1.58)
|
0.96
|
1.05
|
(0.67–1.64)
|
0.84
|
| |
120 ≤ SBP < 130*
|
36/260
|
Ref
| | |
Ref
| | |
| |
130 ≤ SBP < 140
|
60/253
|
1.69
|
(1.12–2.56)
|
0.013
|
1.40
|
(0.92–2.14)
|
0.11
|
| |
SBP ≥ 140
|
168/522
|
1.84
|
(1.28–2.64)
|
0.001
|
1.72
|
(1.19–2.48)
|
0.004
|
|
Treated (N = 399)
|
SBP < 120
|
12/52
|
1.55
|
(0.67–3.62)
|
0.31
|
1.79
|
(0.75–4.26)
|
0.19
|
|
120 ≤ SBP < 130*
|
10/45
|
Ref
| | |
Ref
| | |
|
130 ≤ SBP < 140
|
20/70
|
1.71
|
(0.79–3.68)
|
0.17
|
1.66
|
(0.75–3.67)
|
0.21
|
|
SBP ≥ 140
|
73/232
|
1.54
|
(0.79–2.99)
|
0.2
|
1.78
|
(0.9–3.53)
|
0.1
|
|
Untreated (N = 1049)
|
SBP < 120
|
29/361
|
0.92
|
(0.54–1.56)
|
0.75
|
0.92
|
(0.54–1.57)
|
0.77
|
|
120 ≤ SBP < 130*
|
26/215
|
Ref
| | |
Ref
| | |
|
130 ≤ SBP < 140
|
40/183
|
1.64
|
(1.0–2.71)
|
0.049
|
1.34
|
(0.81–2.23)
|
0.25
|
|
SBP ≥ 140
|
95/290
|
1.88
|
(1.21–2.91)
|
0.005
|
1.81
|
(1.16–2.83)
|
0.009
|
|
Total (N = 1448)
|
DBP < 80
|
136/640
|
1.79
|
(1.22–2.65)
|
0.003
|
1.68
|
(1.13–2.5)
|
0.01
|
| |
80 ≤ DBP < 85*
|
32/276
|
Ref
| | |
Ref
| | |
| |
85 ≤ DBP < 90
|
40/194
|
1.85
|
(1.16–2.96)
|
0.009
|
1.78
|
(1.12–2.85)
|
0.015
|
| |
DBP ≥ 90
|
97/338
|
2.66
|
(1.78–3.98)
|
<0.001
|
2.77
|
(1.85–4.15)
|
<0.001
|
|
Treated (N = 399)
|
DBP < 80
|
43/120
|
2.92
|
(1.42–6.02)
|
0.004
|
2.73
|
1.3–5.7)
|
0.008
|
|
80 ≤ DBP < 85*
|
9/76
|
Ref
| | |
Ref
| | |
|
85 ≤ DBP < 90
|
12/56
|
1.99
|
(0.84–4.74)
|
0.12
|
2.02
|
(0.84–4.88)
|
0.11
|
|
DBP ≥ 90
|
51/147
|
3.68
|
(1.81–7.5)
|
<0.001
|
4.53
|
(2.21–9.3)
|
<0.001
|
|
Untreated (N = 1049)
|
DBP < 80
|
93/520
|
1.47
|
(0.93–2.33)
|
0.1
|
1.41
|
(0.88–2.26)
|
0.15
|
|
80 ≤ DBP < 85*
|
23/200
|
Ref
| | |
Ref
| | |
|
85 ≤ DBP < 90
|
28/138
|
1.88
|
(1.08–3.27)
|
0.025
|
1.88
|
(1.07–3.28)
|
0.027
|
|
DBP ≥ 90
|
46/191
|
2.25
|
(1.36–3.72)
|
0.001
|
2.17
|
(1.3–3.61)
|
0.003
|
|
Total (N = 1448)
|
PP < 39*
|
28/363
|
Ref
| | |
Ref
| | |
|
39 ≤ PP < 51
|
57/382
|
1.41
|
(0.9–2.23)
|
0.13
|
1.27
|
(0.8–2.02)
|
0.3
|
|
51 ≤ PP < 65
|
91/346
|
1.79
|
(1.16–2.76)
|
0.008
|
1.51
|
(0.97–2.33)
|
0.06
|
|
PP ≥ 65
|
129/357
|
1.94
|
(1.26–2.97)
|
0.002
|
1.71
|
(1.11–2.63)
|
0.014
|
|
Treated (N = 399)
|
PP < 49*
|
24/109
|
Ref
| | |
Ref
| | |
|
49 ≤ PP < 60
|
28/94
|
1.27
|
(0.72–2.22)
|
0.4
|
1.29
|
(0.73–2.28)
|
0.34
|
|
60 ≤ PP < 74
|
33/99
|
1.03
|
(0.6–1.78)
|
0.9
|
0.91
|
(0.52–1.59)
|
0.76
|
|
PP ≥ 74
|
30/97
|
0.88
|
(0.5–1.54)
|
0.65
|
0.84
|
(0.48–1.48)
|
0.54
|
|
Untreated (N = 1049)
|
PP < 39*
|
18/279
|
Ref
| | |
Ref
| | |
| |
39 ≤ PP < 48
|
22/263
|
0.88
|
(0.47–1.64)
|
0.68
|
0.66
|
(0.35–1.26)
|
0.21
|
| |
48 ≤ PP < 61
|
56/256
|
1.7
|
(0.99–2.93)
|
0.05
|
1.22
|
(0.7–2.14)
|
0.48
|
| |
PP ≥ 61
|
94/251
|
2.18
|
(1.29–3.69)
|
0.003
|
1.83
|
(1.07–3.12)
|
0.027
|
- Age was adjusted by considering it as the time-scale
- Model 1: Adjusted for sex
- Model 2: Adjusted for sex, BMI, prevalent CVD, diabetes, hypercholesterolemia, eGFR, smoking and anti-hypertensive medication (only for the total population)
- BP blood pressure, SBP systolic blood pressure, DBP diastolic blood pressure, pp pulse pressure, E/N events/N, HR hazard ratio, CI confidence interval
- *Reference intervals
