| |
BP category
|
Model 1
|
Model 2
|
|---|
| |
E/N
|
HR
|
(95% CI)
|
p
|
HR
|
(95% CI)
|
P
|
|---|
|
Total (N = 1232)
|
SBP < 120
|
61/367
|
0.92
|
(0.63–1.34)
|
0.67
|
0.94
|
(0.64–1.38)
|
0.75
|
|
120 ≤ SBP < 130*
|
49/224
|
Ref
| | |
Ref
| | |
|
130 ≤ SBP < 140
|
42/211
|
0.95
|
(0.63–1.44)
|
0.81
|
0.87
|
(0.57–1.32)
|
0.52
|
|
SBP ≥ 140
|
165/430
|
1.67
|
(1.21–2.3)
|
0.002
|
1.68
|
(1.2–2.34)
|
0.002
|
|
Treated (N = 286)
|
SBP < 120
|
10/36
|
1.32
|
(0.5–3.5)
|
0.57
|
1.39
|
(0.51–3.8)
|
0.52
|
|
120 ≤ SBP < 130*
|
7/27
|
Ref
| | |
Ref
| | |
|
130 ≤ SBP < 140
|
12/48
|
1.19
|
(0.46–3.04)
|
0.71
|
1.09
|
(0.42–2.87)
|
0.85
|
|
SBP ≥ 140
|
66/175
|
1.69
|
(0.77–3.69)
|
0.19
|
2.01
|
(0.89–4.57)
|
0.1
|
|
Untreated (N = 946)
|
SBP < 120
|
51/331
|
0.87
|
(0.58–1.31)
|
0.51
|
0.9
|
(0.59–1.36)
|
0.61
|
|
120 ≤ SBP < 130*
|
42/197
|
Ref
| | |
Ref
| | |
|
130 ≤ SBP < 140
|
30/163
|
0.85
|
(0.53–1.36)
|
0.5
|
0.8
|
(0.5–1.29)
|
0.37
|
|
SBP ≥ 140
|
99/255
|
1.62
|
(1.12–2.34)
|
0.01
|
1.64
|
(1.13–2.39)
|
0.009
|
|
Total (N = 1232)
|
DBP < 80
|
132/544
|
1.61
|
(1.13–2.32)
|
0.009
|
1.55
|
(1.08–2.24)
|
0.02
|
|
80 ≤ DBP < 85*
|
38/242
|
Ref
| | |
Ref
| | |
|
85 ≤ DBP < 90
|
45/165
|
1.88
|
(1.22–2.90)
|
0.004
|
1.93
|
(1.25–2.98)
|
0.003
|
|
DBP ≥ 90
|
102/281
|
2.68
|
(1.85–3.89)
|
<0.001
|
2.63
|
(1.8–3.83)
|
<0.001
|
|
Treated (N = 286)
|
DBP < 80
|
24/77
|
2.13
|
(0.95–4.78)
|
0.065
|
2.00
|
(0.89–4.54)
|
0.09
|
|
80 ≤ DBP < 85*
|
8/55
|
Ref
| | |
Ref
| | |
|
85 ≤ DBP < 90
|
11/38
|
2.1
|
(0.84–5.22)
|
0.11
|
1.96
|
(0.77–4.95)
|
0.16
|
|
DBP ≥ 90
|
52/116
|
4.02
|
(1.9–4.85)
|
< 0.001
|
4.54
|
(2.13–9.67)
|
<0.001
|
|
Untreated (N = 946)
|
DBP < 80
|
108/467
|
1.5
|
(1.0–2.25)
|
0.049
|
1.43
|
(0.95–2.16)
|
0.09
|
|
80 ≤ DBP < 85*
|
30/187
|
Ref
| | |
Ref
| | |
|
85 ≤ DBP < 90
|
34/127
|
1.84
|
(1.13–3.01)
|
0.015
|
1.94
|
(1.19–3.18)
|
0.008
|
|
DBP ≥ 90
|
50/165
|
2.09
|
(1.33–3.29)
|
0.001
|
1.95
|
(1.23–3.08)
|
0.004
|
|
Total (N = 1232)
|
PP < 40*
|
46/327
|
Ref
| | |
Ref
| | |
|
40 ≤ PP < 50
|
70/291
|
1.5
|
(1.03–2.19)
|
0.034
|
1.44
|
(0.98–2.1)
|
0.06
|
|
50 ≤ PP < 64
|
79/307
|
1.43
|
(0.98–2.08)
|
0.06
|
1.28
|
(0.88–1.87)
|
0.2
|
|
PP ≥ 64
|
122/307
|
2.13
|
(1.48–3.06)
|
<0.001
|
1.92
|
(1.33–2.78)
|
0.001
|
|
Treated (N = 286)
|
PP < 40*
|
12/37
|
Ref
| | |
Ref
| | |
|
40 ≤ PP < 50
|
12/42
|
0.93
|
(0.42–2.09)
|
0.87
|
1.08
|
(0.47–2.50)
|
0.86
|
|
50 ≤ PP < 64
|
26/83
|
0.95
|
(0.47–1.93)
|
0.9
|
1.04
|
(0.51–2.13)
|
0.91
|
|
PP ≥ 64
|
45/124
|
1.06
|
(0.55–2.06)
|
0.86
|
1.16
|
(0.59–2.27)
|
0.66
|
|
Untreated (N = 946)
|
PP < 40*
|
34/290
|
Ref
| | |
Ref
| | |
|
40 ≤ PP < 50
|
58/249
|
1.67
|
(1.09–2.57)
|
0.019
|
1.52
|
(0.98–2.36)
|
0.058
|
|
50 ≤ PP < 64
|
53/224
|
1.5
|
(0.96–2.34)
|
0.075
|
1.31
|
(0.84–2.06)
|
0.24
|
|
PP ≥ 64
|
77/183
|
2.54
|
(1.65–3.91)
|
<0.001
|
2.34
|
(1.51–3.63)
|
< 0.001
|
- Age was adjusted by considering it as the time-scale
- Model 1: Adjusted for sex
- Model 2: Adjusted for sex, BMI, diabetes, hypercholesterolemia, eGFR, smoking and anti-hypertensive medication (only for total population)
- BP blood pressure, SBP systolic blood pressure, DBP diastolic blood pressure, pp pulse pressure, E/N events/N, HR hazard ratio, CI confidence interval
- *Reference intervals
