Fig. 3

Diagnostic value of NTT, MIAT and EMX2OS expressions in ME/CFS. PCA showing the distribution of ME/CFS and controls on two-dimension plots differentiated by values derived from the expression levels of NTT, MIAT and EMX2OS (a) or from the expression levels of any two of the three lncRNAs (b–d). e Receiver-operating characteristic (ROC) curve analysis of the three-lncRNA signature to discriminate ME/CFS patients from healthy controls. AUC = 0.82 when the criteria is increased expression (ΔCT below the optimal cutoff) of any two of the three lncRNAs (NTT, MIAT and EMX2OS)