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Table 3 The association between metabolic hormones and mitochondrial DNA content

From: Cord blood leptin and insulin levels in association with mitochondrial DNA content

 

Effect size (95% CI)

p-value

Main results: separate models for metabolic hormones (n = 236)

 Insulin

1.60% (0.31–2.91)

0.02

 Leptin

4.49% (1.15–7.93)

0.008

Sensitivity: combined model including both metabolic hormones (n = 236)

 Insulin

1.29% (− 0.02–2.61)

0.05

 Leptin

3.77% (0.40–7.25)

0.03

Sensitivity: exclusion of obese mothers (n = 215)

 Insulin

1.72% (0.37–3.09)

0.01

 Leptin

4.75% (1.25–8.37)

0.008

Sensitivity: effect modification* of newborns’ sex for the relation between mtDNA content and insulin

 Girls

0.57% (− 1.19–2.36)

0.53

 Boys

1.61% (0.32–2.91)

0.01

  1. The estimated effects (95% CI) are represented as a relative % change in the mtDNA content for a interquartile range increase in hormone levels. Models were adjusted for newborns’ sex, gestational age, growth rate, ethnicity, maternal pre-pregnancy BMI, maternal age, household education, parity, smoking during pregnancy and cord blood thrombocyte count
  2. * p for interaction term = 0.10