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Table 3 The association between metabolic hormones and mitochondrial DNA content

From: Cord blood leptin and insulin levels in association with mitochondrial DNA content

  Effect size (95% CI) p-value
Main results: separate models for metabolic hormones (n = 236)
 Insulin 1.60% (0.31–2.91) 0.02
 Leptin 4.49% (1.15–7.93) 0.008
Sensitivity: combined model including both metabolic hormones (n = 236)
 Insulin 1.29% (− 0.02–2.61) 0.05
 Leptin 3.77% (0.40–7.25) 0.03
Sensitivity: exclusion of obese mothers (n = 215)
 Insulin 1.72% (0.37–3.09) 0.01
 Leptin 4.75% (1.25–8.37) 0.008
Sensitivity: effect modification* of newborns’ sex for the relation between mtDNA content and insulin
 Girls 0.57% (− 1.19–2.36) 0.53
 Boys 1.61% (0.32–2.91) 0.01
  1. The estimated effects (95% CI) are represented as a relative % change in the mtDNA content for a interquartile range increase in hormone levels. Models were adjusted for newborns’ sex, gestational age, growth rate, ethnicity, maternal pre-pregnancy BMI, maternal age, household education, parity, smoking during pregnancy and cord blood thrombocyte count
  2. * p for interaction term = 0.10