Table 4 Canonical pathway analysis for differentially expressed (DE) genes involved in ARPE19-HBx and ARPE19-control cells, pre- and post-UV irradiation
Pathway name | Genes in overlap (k) | P value |
|---|---|---|
HBx vs. mock | Before UV irradiation | |
1. Prostaglandin metabolism | 9 | 1.52E−04 |
2. p53 signaling pathway | 9 | 2.63E−04 |
3. TNF signaling pathway | 10 | 1.39E−03 |
4. Cytokine-cytokine receptor | 14 | 5.43E−03 |
5. ECM-receptor interaction | 8 | 6.31E−03 |
6. Steroidogenesis | 6 | 7.62E−03 |
7. Cancer-related pathways | 19 | 1.03E−02 |
8. PI3K-Akt signaling pathway | 17 | 1.37E−02 |
HBx vs. mock | Post UV irradiation | |
1. DNA replication | 25 | 7.62E−12 |
2. Cell cycle | 51 | 2.57E−11 |
3. Mismatch repair | 15 | 1.05E−06 |
4. p53 signaling pathway | 26 | 1.31E−05 |
5. Cancer-related pathways | 85 | 1.36E−03 |
6. Circadian rhythm | 13 | 1.64E−03 |
7. TNF signaling pathway | 29 | 3.03E−03 |
8. Base excision repair | 13 | 3.05E−03 |
9. Nucleotide excision repair | 14 | 2.57E−02 |
10 Homologous recombination | 11 | 1.01E−02 |