Fig. 4

Function of miR-29c on macrophage in regulating Th cell differentiation. ROR-γt and GATA-3 expression were increased in CD4⁺ T cells compared to control group when CD4⁺ T cells co-cultured with macrophage transfected with anti-miR-29c. ROR-γt expression was decreased when CD4⁺ T cells co-cultured with macrophage transfected with pLenti-miR-29c. Levels of IL-4 and IL-17 in supernatants were increased in anti-miR-29c group and IL-17 was decreased in pLenti-miR-29c group. NS not significant; **P < 0.01; ***P < 0.001. Data are shown as mean ± STD