TY - JOUR AU - Sun, Zhixiang AU - Zhao, Tianyun AU - Lv, Shaojun AU - Gao, Ying AU - Masters, Joe AU - Weng, Hao PY - 2018 DA - 2018/07/21 TI - Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits JO - Journal of Translational Medicine SP - 209 VL - 16 IS - 1 AB - Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effects of dexmedetomidine on the toll-like receptor 4 (TLR4)-mediated nuclear factor κB (NF-κB) inflammatory system and caspase-3 dependent apoptosis induced by spinal cord ischemia–reperfusion injury. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-018-1583-7 DO - 10.1186/s12967-018-1583-7 ID - Sun2018 ER -