Fig. 1

Heat map showing differential miRNA expression profiles between GC tissues and normal gastric tissues according to Ming’s classification. Each column represents a paired sample and each row represents a miRNA. Representative HE staining showed significantly different tumor growth patterns in Ming’s classification of GC (a expanding type; b infiltrative type). c, d Hierarchical cluster analysis of the most up and down regulated miRNAs in two types of GC. Each group contains three paired samples. Red strip represents high relative expression and green strip represents low relative expression. e Many miRNAs showed differentially expression between Ming’s classification cell lines, GES-1 cell line was used as control. f The miRNAs that can be sponged by circHIPK3 according to previous reports