Table 2 Comparison of CR rate among UGT1A1 genotypes after 2 courses of Ara-C based chemotherapy
SNP | Genotype | Total, n | CR, n (%) | Non-CR, n (%) | OR (95% CI) | P value |
|---|---|---|---|---|---|---|
UGT1A1*6 | *1/*1 | 471 | 315 (66.9) | 156 (33.1) | 1.00 (reference) | Â |
*1/*6 | 202 | 155 (76.7) | 47 (23.3) | 0.612 (0.419–0.894) | 0.011 | |
*6/*6 | 24 | 19 (79.2) | 5 (20.8) | 0.531 (0.195–1.450) | 0.353 | |
*6/− | 226 | 174 (77.0) | 52 (23.0) | 0.604 (0.419–0.869) | 0.007 | |
UGT1A1*28 | *1/*1 | 553 | 379 (68.5) | 174 (31.5) | 1.00 (reference) | Â |
*1/*28 | 130 | 97 (74.6) | 33 (25.4) | 0.741 (0.480–1.144) | 0.176 | |
*28/*28 | 14 | 13 (92.9) | 1 (7.1) | 0.168 (0.022–1.291) | 0.086 | |
*28/− | 144 | 110 (76.4) | 34 (23.6) | 0.673 (0.440–1.029) | 0.068 | |
Combined genotypes | *1/*1 for both loci | 359 | 229 (63.8) | 130 (36.2) | 1.00 (reference) | Â |
*6/− alone | 194 | 150 (77.3) | 44 (22.7) | 0.517 (0.347–0.770) | 0.001 | |
*28/− alone | 112 | 86 (76.8) | 26 (23.2) | 0.533 (0.327–0.868) | 0.011 | |
*6/− and *28/− | 32 | 24 (75.0) | 8 (25.0) | 0.587 (0.256–1.345) | 0.208 | |
*6/− or *28/− | 338 | 260 (76.9) | 78 (23.1) | 0.528 (0.379–0.737) | 1.7 × 10−4 |