Clinical features | Total (n = 726) | UGT1A1*28 | UGT1A1*6 | ||||
---|---|---|---|---|---|---|---|
*1/*1 (n = 579) | *28/− (n = 147) | P value | *1/*1 (n = 493) | *6/− (n = 233) | P value | ||
Age, years | 41 ± 14 | 41 ± 14 | 41 ± 15 | 0.816 | 41 ± 14 | 42 ± 14 | 0.799 |
Male sex, n (%) | 400 (55.1) | 317 (54.7) | 83 (56.5) | 0.709 | 280 (56.8) | 120 (51.5) | 0.181 |
Smoking, n (%) | 171(23.6) | 141 (24.4) | 30 (20.4) | 0.314 | 125 (25.4) | 46 (19.7) | 0.096 |
Drinking, n (%) | 108 (14.9) | 91 (15.7) | 17 (11.6) | 0.206 | 69 (14.0) | 39 (16.7) | 0.332 |
FAB classification, n (%) | |||||||
M0 | 3 (0.4) | 2 (0.3) | 1 (0.7) | 0.918 | 1 (0.2) | 2 (0.9) | 0.204 |
M1 | 38 (5.2) | 10 (5.2) | 11 (7.5) | 33 (6.7) | 8 (3.4) | ||
M2 | 372 (51.2) | 298 (51.5) | 74 (50.3) | 258 (52.3) | 114 (48.9) | ||
M4 | 149 (20.5) | 118 (20.4) | 28 (19.0) | 94 (19.1) | 52 (23.3) | ||
M5 | 146 (20.1) | 117 (20.2) | 29 (19.7) | 97 (19.7) | 49 (21.0) | ||
M6 | 17 (2.3) | 13 (2.2) | 4 (2.7) | 9 (1.8) | 8 (3.4) | ||
M7 | 1 (0.1) | 1 (0.2) | – | 1 (0.2) | – | ||
AML type, n (%) | |||||||
De novo AML | 692 (95.3) | 551 (95.2) | 141 (95.9) | 0.699 | 469 (95.1) | 223 (95.7) | 0.732 |
Secondary AML | 34 (4.7) | 28 (4.8) | 6 (4.1) | 24 (4.9) | 10 (4.7) | ||
Parameters at diagnosis | |||||||
WBC count, × 109/l | 40.07 ± 62.15 | 39.54 ± 62.53 | 42.17 ± 60.80 | 0.650 | 40.70 ± 59.07 | 38.72 ± 68.37 | 0.691 |
RBC count, × 1012/l | 2.33 ± 1.64 | 2.26 ± 0.77 | 2.60 ± 3.33 | 0.232 | 2.39 ± 1.93 | 2.21 ± 0.73 | 0.173 |
Hemoglobin, g/l | 73.98 ± 21.68 | 73.64 ± 21.86 | 75.36 ± 20.99 | 0.395 | 74.61 ± 22.25 | 72.66 ± 20.44 | 0.261 |
Platelets count, × 109/l | 55.41 ± 64.40 | 54.70 ± 60.73 | 58.22 ± 77.45 | 0.559 | 53.90 ± 61.17 | 58.62 ± 70.80 | 0.360 |
Neutrophil count, × 109/l | 13.44 ± 33.00 | 13.51 ± 34.56 | 13.14 ± 26.04 | 0.905 | 13.98 ± 32.47 | 12.29 ± 34.23 | 0.525 |
LDH, U/l | 564.6 ± 725.2 | 561.2 ± 771.9 | 578.2 ± 501.1 | 0.806 | 566.4 ± 758.5 | 560.9 ± 651.7 | 0.926 |
Bone marrow blasts, % | 65.37 ± 20.88 | 64.94 ± 20.81 | 67.02 ± 21.12 | 0.291 | 65.98 ± 21.21 | 64.08 ± 20.15 | 0.267 |
Risk stratifications, n (%) | |||||||
Low risk | 152 (20.9) | 115 (19.9) | 37 (25.2) | 0.553 | 98 (19.9) | 54 (23.2) | 0.142 |
Intermediate risk | 330 (45.5) | 267 (46.1) | 63 (42.9) | 230 (46.7) | 100 (42.9) | ||
High risk | 140 (19.3) | 114 (19.7) | 26 (17.7) | 102 (20.7) | 38 (16.3) | ||
Unknown | 104 (14.3) | 83(14.3) | 21 (14.3) | 63 (12.8) | 41 (17.6) | ||
HSCT, n (%) | 124 (17.1) | 94 (16.2) | 30 (20.4) | 0.230 | 89 (18.1) | 35 (15.0) | 0.311 |