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Table 3 Accuracy of the six-cytokine biosignature in the diagnosis of active TB

From: Screening and identification of a six-cytokine biosignature for detecting TB infection and discriminating active from latent TB

 

Sensitivity

Specificity

PPV

NPV

Accuracy

Biomarker screening group (n = 88)

 %, (n/N)

96.4 (27/28)

98.3 (59/60)

96.4 (27/28)

98.3 (59/60)

97.7 (86/88)

 95% CI

80.8–100.0

90.3–100.0

80.8–100.0

90.3–100.0

91.6–99.9

Biomarker validation group (n = 216)

 %, (n/N)

88.2 (67/76)

92.1 (129/140)

85.9 (67/78)

93.5 (129/138)

90.7 (196/216)

 95% CI

78.8–93.9

86.3–96.7

76.3–92.1

87.9–96.7

86.1–94.0

Clinical validation group (n = 194)

 %, (n/N)

85.7 (78/91)

91.3 (94/103)

89.7 (78/87)

87.9 (94/107)

88.7 (172/194)

 95% CI

76.9–91.6

84.0–95.5

81.3–94.7

80.2–92.9

83.4–92.5

  1. NPV negative predictive value, PPV positive predictive value