Fig. 4

Study decision tree and diagnostic performance of single and combined tuberculosis (TB) diagnostic tests. The left side depicts the decision analysis of different diagnostic tests in the clinical validation cohort. The square represents a decision node, circles represent chance nodes, and triangles indicate terminal nodes. The right side of this graph shows the sensitivity, specificity, and accuracy of the diagnostic performance of each diagnostic test alone, and the additional gain when combining the six-cytokine biosignature test with either AFB or QFT in ATB suspects from a clinical validation cohort. AFB acid fast bacilli, QFT QuantiFERON TB GOLD in-tube, 6-cytokine six-cytokine biosignature test, Pos. positive; Neg. negative, ATB patients with active TB, NTB subjects without ATB disease