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Table 4 Logistic regression analysis of risk factors for low MHC class I expression

From: Comparison of immunological characteristics between paired mismatch repair-proficient and -deficient colorectal cancer patients

Factors Univariate analysis Multivariate analysis
OR (95% CI) p-value OR (95% CI) p-value
Age at diagnosis (≥ 60) 0.60 (0.37–0.98) 0.042 0.99 (0.54–1.85) 0.998
Gender (female) 0.72 (0.44–1.17) 0.187   
Primary tumor site 0.136   
 Left colon 0.79 (0.41–1.50) 0.464   
 Right colon 1.36 (0.74–2.50) 0.323   
 Rectum (reference)   
Stage (7th AJCC) 0.245   
 I 0.47 (0.17–1.35) 0.161   
 II 0.38 (0.15–0.97) 0.044   
 III 0.43 (0.16–1.17) 0.097   
 IV (reference)   
Tumor stage 0.005   0.122
 T1 0.89 (0.27–2.99) 0.849 6.78 (0.97–47.42) 0.054
 T2 0.37 (0.16–0.86) 0.02 0.91 (0.22–3.72) 0.897
 T3 0.35 (0.19–0.65) 0.001 0.71 (0.33–1.52) 0.377
 T4 (reference)
Node stage (positive) 0.92 (0.54–1.56) 0.753   
Negative lymph nodes (high) 1.42 (0.89–2.28) 0.143   
Tumor histological grade 0.004   0.117
 Well-differentiated 0.00 0.999 0.00 0.999
 Moderately differentiated 0.38 (0.22–0.65) < 0.001 0.47 (0.23–0.94) 0.034
 Poorly differentiated 0.76 (0.38–1.52) 0.436 0.99 (0.42–2.38) 0.989
 Mucinous (reference)
Nerve invasion (no) 1.66 (0.73–3.77) 0.227   
Vascular invasion (no) 1.10 (0.51–2.38) 0.814   
MMR status (dMMR) 15.16 (7.81–29.42) < 0.001 15.34 (7.24–32.50) < 0.001
CD3 expression (high) 0.91 (0.54–1.52) 0.714   
CD4 expression (high) 0.57 (0.35–0.93) 0.025 1.05 (0.57–1.96) 0.871
CD8 expression (high) 1.42 (0.83–2.42) 0.198   
CD56 expression (high) 0.49 (0.30–0.79) 0.004 0.92 (0.50–1.70) 0.795
PD-1 expression (high) 0.95 (0.56–1.61) 0.855   
PD-L1 expression (positive) 0.70 (0.43–1.12) 0.133   
  1. OR: odds ratio; 95% CI: 95% confidence interval
  2. Only the meaningful factors (p < 0.05) in univariate analysis were brought into the multivariate analysis