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Table 4 Associations between differentially expressed genes in the TGFβ-signaling pathway and differential miRNA expression

From: The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

Gene name

Fold change

miRNA

Tumor mean

Tumor SD

T Pct with expression

Normal mean

Normal SD

N Pct with expression

Fold change

(95% CI)

% < 0.67

% > 1.5

Beta

FDR p-value

RBL1

2.30

hsa-miR-1246

629.21

296.96

100.00

412.81

121.13

100.00

1.52

(1.42, 1.63)

2.90

47.83

0.30

0.0116

  

hsa-miR-17-5p a

61.04

48.49

98.47

16.38

10.13

95.93

3.73

(3.24, 4.22)

3.86

83.57

0.32

0.0116

  

hsa-miR-196b-5p

17.89

19.62

76.76

5.53

5.43

71.00

3.24

(2.60, 3.88)

–b

–

0.23

0.0407

  

hsa-miR-19b-3p

29.80

23.72

93.13

10.42

9.70

83.84

2.86

(2.46, 3.26)

4.83

72.95

0.23

0.0407

  

hsa-miR-20a-5p

70.78

59.44

97.83

17.61

12.25

94.56

4.02

(3.47, 4.57)

3.86

83.57

0.32

0.0116

  

hsa-miR-20b-5p

17.65

15.14

88.59

3.30

3.59

61.07

5.35

(4.36, 6.34)

–

–

0.27

0.025

  

hsa-miR-25-3p

30.05

23.13

95.93

12.78

8.12

89.80

2.35

(2.05, 2.65)

4.83

69.57

0.28

0.0181

  

hsa-miR-3651

58.66

34.62

99.26

25.92

12.63

99.10

2.26

(2.06, 2.46)

4.35

76.81

0.28

0.0116

  

hsa-miR-663b

65.50

24.80

100.00

32.21

14.68

100.00

2.03

(1.87, 2.20)

3.86

79.71

0.25

0.0222

  

hsa-miR-92a-3p

121.60

104.09

99.84

41.18

24.92

99.58

2.95

(2.58, 3.33)

3.86

80.19

0.38

0.0116

  

hsa-miR-93-5p

41.72

32.63

97.78

15.20

9.19

94.61

2.74

(2.39, 3.09)

2.90

77.78

0.28

0.0116

TGFBR1

1.52

hsa-let-7i-5p

62.16

37.92

98.63

39.97

21.97

98.63

1.56

(1.41, 1.70)

5.31

45.89

0.25

0.031

  

hsa-miR-1203

1.76

1.49

43.05

2.83

1.17

64.55

0.62

(0.53, 0.72)

–

–

− 0.23

0.031

  

hsa-miR-199a-3p

44.83

37.37

95.30

22.53

15.51

94.24

1.99

(1.73, 2.25)

9.66

55.07

0.24

0.031

  

hsa-miR-199a-5p

20.18

17.86

90.28

9.28

6.76

85.63

2.17

(1.86, 2.49)

7.73

53.14

0.22

0.0458

  

hsa-miR-2117

1.50

1.98

25.78

4.09

2.08

54.04

0.37

(0.27, 0.46)

–

–

− 0.22

0.0358

  

hsa-miR-214-3p

13.24

10.86

90.86

6.13

4.14

85.79

2.16

(1.87, 2.45)

6.28

52.17

0.26

0.031

  

hsa-miR-21-5p

463.11

312.01

99.52

167.37

118.91

99.52

2.77

(2.47, 3.06)

4.35

84.06

0.25

0.031

  

hsa-miR-23a-3p

174.68

110.22

99.42

87.53

50.12

99.47

2.00

(1.81, 2.19)

4.35

65.70

0.25

0.031

  

hsa-miR-24-3p

106.75

61.76

99.63

62.39

29.22

99.74

1.71

(1.57, 1.85)

3.38

56.04

0.24

0.0318

  

hsa-miR-331-3p

14.64

11.75

95.93

9.30

5.88

93.24

1.57

(1.39, 1.76)

5.31

50.24

0.24

0.031

  

hsa-miR-6071

0.97

1.07

15.00

1.70

1.11

37.08

0.57

(0.38, 0.76)

–

–

− 0.22

0.0458

TGIF2

2.59

hsa-miR-106b-5p

15.90

13.81

88.54

5.19

4.13

71.26

3.06

(2.61, 3.51)

–

–

0.23

0.0141

  

hsa-miR-1246

629.21

296.96

100.00

412.81

121.13

100.00

1.52

(1.42, 1.63)

2.90

47.83

0.21

0.023

  

hsa-miR-1291

5.52

3.41

76.33

3.67

2.12

69.10

1.51

(1.33, 1.68)

–

–

0.20

0.0257

  

hsa-miR-130b-3p

8.74

4.50

85.68

4.89

3.13

72.05

1.79

(1.60, 1.97)

–

–

0.31

0.0035

  

hsa-miR-151a-3p

5.15

3.49

51.56

1.56

1.89

33.81

3.31

(2.59, 4.03)

–

–

0.25

0.0069

  

hsa-miR-17-5p

61.04

48.49

98.47

16.38

10.13

95.93

3.73

(3.24, 4.22)

3.86

83.57

0.36

0.0035

  

hsa-miR-193b-3p

9.12

7.78

86.85

5.42

3.77

83.20

1.68

(1.47, 1.90)

5.80

41.55

0.19

0.0347

  

hsa-miR-196a-5p

6.70

7.13

63.71

4.21

3.13

66.93

1.59

(1.31, 1.88)

–

–

0.25

0.0064

  

hsa-miR-196b-5p

17.89

19.62

76.76

5.53

5.43

71.00

3.24

(2.60, 3.88)

–

–

0.36

0.0035

  

hsa-miR-19b-3p

29.80

23.72

93.13

10.42

9.70

83.84

2.86

(2.46, 3.26)

4.83

72.95

0.30

0.0035

  

hsa-miR-20a-5p

70.78

59.44

97.83

17.61

12.25

94.56

4.02

(3.47, 4.57)

3.86

83.57

0.34

0.0035

  

hsa-miR-20b-5p

17.65

15.14

88.59

3.30

3.59

61.07

5.35

(4.36, 6.34)

–

–

0.38

0.0035

  

hsa-miR-221-3p

13.53

12.32

85.42

4.12

4.07

63.71

3.28

(2.73, 3.84)

–

–

0.21

0.0214

  

hsa-miR-25-3p

30.05

23.13

95.93

12.78

8.12

89.80

2.35

(2.05, 2.65)

4.83

69.57

0.31

0.0035

  

hsa-miR-361-5p

11.62

9.05

88.59

6.20

3.98

81.56

1.87

(1.64, 2.11)

5.31

50.72

0.32

0.0035

  

hsa-miR-3651

58.66

34.62

99.26

25.92

12.63

99.10

2.26

(2.06, 2.46)

4.35

76.81

0.25

0.0086

  

hsa-miR-375

20.50

26.15

82.62

54.53

35.84

99.42

0.38

(0.30, 0.45)

66.18

10.14

− 0.22

0.0192

  

hsa-miR-424-3p

39.81

20.91

99.89

25.37

8.09

99.95

1.57

(1.45, 1.69)

3.86

47.83

0.22

0.0167

  

hsa-miR-425-5p

11.76

8.74

83.62

6.97

4.39

80.35

1.69

(1.51, 1.87)

6.76

47.83

0.19

0.0299

  

hsa-miR-4749-3p

8.01

4.10

95.88

12.04

3.97

99.05

0.67

(0.61, 0.72)

42.51

4.83

− 0.22

0.0148

  

hsa-miR-483-3p

9.73

28.36

43.21

1.88

2.09

48.97

5.17

(2.09, 8.25)

–

–

0.22

0.0124

  

hsa-miR-501-3p

7.07

3.42

95.99

2.95

1.65

84.79

2.39

(2.15, 2.64)

4.35

69.08

0.29

0.0035

  

hsa-miR-583

6.61

3.92

87.43

3.22

3.20

71.95

2.05

(1.73, 2.37)

–

–

0.18

0.046

  

hsa-miR-663b

65.50

24.80

100.00

32.21

14.68

100.00

2.03

(1.87, 2.20)

3.86

79.71

0.25

0.0051

  

hsa-miR-92a-3p

121.60

104.09

99.84

41.18

24.92

99.58

2.95

(2.58, 3.33)

3.86

80.19

0.38

0.0035

  

hsa-miR-93-5p

41.72

32.63

97.78

15.20

9.19

94.61

2.74

(2.39, 3.09)

2.90

77.78

0.27

0.0051

INHBA

9.34

hsa-let-7i-5p

62.16

37.92

98.63

39.97

21.97

98.63

1.56

(1.41, 1.70)

5.31

45.89

0.26

0.0452

  

hsa-miR-199a-3p

44.83

37.37

95.30

22.53

15.51

94.24

1.99

(1.73, 2.25)

9.66

55.07

0.32

0.0163

  

hsa-miR-199a-5p

20.18

17.86

90.28

9.28

6.76

85.63

2.17

(1.86, 2.49)

7.73

53.14

0.31

0.0203

  

hsa-miR-199b-5p

4.69

4.05

39.41

1.53

1.67

32.54

3.07

(2.28, 3.87)

–

–

0.29

0.0163

  

hsa-miR-214-3p

13.24

10.86

90.86

6.13

4.14

85.79

2.16

(1.87, 2.45)

6.28

52.17

0.34

0.0163

  

hsa-miR-21-5p

463.11

312.01

99.52

167.37

118.91

99.52

2.77

(2.47, 3.06)

4.35

84.06

0.28

0.0163

  

hsa-miR-934

4.36

3.61

82.99

0.94

1.36

45.59

4.66

(3.44, 5.88)

–

–

0.40

0.0163

E2F5

1.52

hsa-miR-17-5p

61.04

48.49

98.47

16.38

10.13

95.93

3.73

(3.24, 4.22)

3.86

83.57

0.30

0.0407

  

hsa-miR-20a-5p

70.78

59.44

97.83

17.61

12.25

94.56

4.02

(3.47, 4.57)

3.86

83.57

0.31

0.0407

MYC

3.70

hsa-miR-1246

629.21

296.96

100.00

412.81

121.13

100.00

1.52

(1.42, 1.63)

2.90

47.83

0.27

0.0163

  

hsa-miR-17-5p

61.04

48.49

98.47

16.38

10.13

95.93

3.73

(3.24, 4.22)

3.86

83.57

0.35

0.0136

  

hsa-miR-19b-3p

29.80

23.72

93.13

10.42

9.70

83.84

2.86

(2.46, 3.26)

4.83

72.95

0.27

0.0163

  

hsa-miR-20a-5p

70.78

59.44

97.83

17.61

12.25

94.56

4.02

(3.47, 4.57)

3.86

83.57

0.33

0.0136

  

hsa-miR-20b-5p

17.65

15.14

88.59

3.30

3.59

61.07

5.35

(4.36, 6.34)

–

–

0.31

0.0163

  

hsa-miR-3651

58.66

34.62

99.26

25.92

12.63

99.10

2.26

(2.06, 2.46)

4.35

76.81

0.28

0.0188

  

hsa-miR-375

20.50

26.15

82.62

54.53

35.84

99.42

0.38

(0.30, 0.45)

66.18

10.14

− 0.29

0.0136

  

hsa-miR-501-3p

7.07

3.42

95.99

2.95

1.65

84.79

2.39

(2.15, 2.64)

4.35

69.08

0.26

0.0188

  

hsa-miR-583

6.61

3.92

87.43

3.22

3.20

71.95

2.05

(1.73, 2.37)

–

–

0.26

0.0233

  

hsa-miR-663a

374.83

174.81

100.00

234.91

83.58

100.00

1.60

(1.49, 1.70)

3.86

56.04

0.28

0.0188

  

hsa-miR-663b

65.50

24.80

100.00

32.21

14.68

100.00

2.03

(1.87, 2.20)

3.86

79.71

0.33

0.0136

  

hsa-miR-92a-3p

121.60

104.09

99.84

41.18

24.92

99.58

2.95

(2.58, 3.33)

3.86

80.19

0.32

0.0136

THBS1

0.66

hsa-miR-145-5p

132.97

156.85

99.84

223.14

182.21

100.00

0.60

(0.48, 0.71)

66.18

12.56

0.29

0.0407

TFDP1

2.21

hsa-miR-145-5p

132.97

156.85

99.84

223.14

182.21

100.00

0.60

(0.48, 0.71)

66.18

12.56

− 0.25

0.0488

  

hsa-miR-17-5p

61.04

48.49

98.47

16.38

10.13

95.93

3.73

(3.24, 4.22)

3.86

83.57

0.33

0.0163

  

hsa-miR-19b-3p

29.80

23.72

93.13

10.42

9.70

83.84

2.86

(2.46, 3.26)

4.83

72.95

0.29

0.0233

  

hsa-miR-20a-5p

70.78

59.44

97.83

17.61

12.25

94.56

4.02

(3.47, 4.57)

3.86

83.57

0.32

0.0163

  

hsa-miR-20b-5p

17.65

15.14

88.59

3.30

3.59

61.07

5.35

(4.36, 6.34)

–

–

0.31

0.0163

  

hsa-miR-21-3p

22.68

12.22

96.51

9.89

5.94

87.00

2.29

(2.06, 2.52)

3.38

71.98

0.29

0.0233

  

hsa-miR-92a-3p

121.60

104.09

99.84

41.18

24.92

99.58

2.95

(2.58, 3.33)

3.86

80.19

0.34

0.0163

  1. aBolditalics text indicates seed-region match between miRNA and mRNA
  2. bValues could not be meaningfully calculated when less than 80% of the population had either a tumor or normal expression value of 0
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Journal of Translational Medicine

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