Fig. 2

Integrated gene map of the variant data from the Oncomine Focus Assay panels (OFA) and Cancer Hotspot v2 (CHPv2) panel (ThermoFisher Scientific, USA) identified in the CUP cohort. This gene map shows the pattern of case-specific, concurrent and mutually exclusive mutations identified in the CUP cases. Each column represents an individual case and each row denotes a specific gene assigned to one of two functional categories (black—hotspot variant; grey—druggable target). The list of genes includes only those found to be aberrantly expressed within the cohort, and represents a subset of the total number of genes interrogated by both panels. No variants were identified in four cases and were not included in the figure