Fig. 9

Survival analysis of Sunitinib, Chloroquine and Gemcitabine combinatorial treatment on orthotopic KPCP1 murine models in vivo. a Survival proportions of mouse PDAC models with KPCP1 cell implantation into the pancreatic tissue. Mice exhibiting clincial PDAC growth were treated with various combinations of sunitinib (Sun), chloroquine (CQ) and gemcitabine/paclitaxel (Chemo). The triplet combination shows highest survival rate (p < 0.001). The doublet combination treatments of Chemo + Sun, Chemo + CQ showed significant increase (p < 0.01) in survival compared to single treatment groups, while the Sun + CQ groups did not show significant increase in survival rate compared to either sham or single treatment groups. b Bar-charts showing mean pancreas weight after 4-weeks post-treatment in various treatment groups. The pancreas weight is significantly reduced in the Chemo + Sun (p < 0.05), Chemo + CQ (p < 0.01) and Chemo + Sun + CQ (p < 0.001) treatment groups, compared to Chemo or Sun alone treatment groups, while the monotherapy treatments or Sun + CQ treatment did not show any significant reduction in pancreatic mass. Sham vehicle control, Chemo gemcitabine plus paclitaxel, Sun sunitinib, CQ chloroquine